ArticleFrontiers in dental medicine2024
MicroRNA-21-5p profile in the alveolar bone following tooth extraction in medication-related osteonecrosis of the jaw rat model.
Article in Frontiers in dental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Localized therapeutic strategy based on microRNA-21-loaded mesoporous silica nanoparticles hydrogel improves bone repair in medication-related osteonecrosis of the jaw.Journal of orthopaedic surgery and research · 2025Article
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4 authors.
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Abstract
Objective: This study aimed to compare microRNA-21-5p expressions at the extraction wound in the maxillary bones of rats with medication-related osteonecrosis of the jaw (MRONJ) and normal rats at different time points. Materials and methods: In total, 18 female, 8-week-old Sprague-Dawley rats were randomly assigned to the experimental group ( Results: From their gross appearance, the rats that received zoledronate and dexamethasone developed MRONJ as demonstrated by non-healing wounds and exposed bone at 14 and 28 days post-extraction in contrast to the controls. The RT-PCR showed that the expression levels of miRNA-21-5p were relatively higher in the MRONJ rats compared to the control rats at day 14 and then the difference was lower at day 28 post-tooth extraction. Conclusion: The findings indicated that the microRNA-21-5p expression levels varied during the socket healing process in the MRONJ rats, reaching a peak at 2 weeks after tooth extraction.
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