SynthesisFrontiers in nutrition2025
Effect of long-term exercise on circulating ghrelin in overweight and obese individuals: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Exercise modulates food reward: neurobiological mechanisms and implications for weight management.Frontiers in nutrition · 2026Review
- The Positive Effects of Exercise on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Optimal exercise modalities and dose selection to reduce leptin levels in overweight or obese individuals: a network meta-analysis and dose-response relationship study.BMC sports science, medicine & rehabilitation · 2025Article
- Effects of exercise alone or combined with dietary restriction on leptin and adiponectin in overweight or obese individuals: a network meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Type 2 Diabetes and the Multifaceted Gut-X Axes.Nutrients · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Ghrelin, also known as the "hunger hormone," is a pivotal hormone in controlling appetite, and it is the only known gastrointestinal hormone that promotes food intake, contributing to the regulation of energy balance and body weight. However, studies on the long-term effects of exercise on ghrelin levels in obese populations have shown conflicting results. This study aims to summarize RCT experiments exploring changes in ghrelin levels following long-term exercise in obese or overweight individuals through meta-analysis. Methods: This study employed meta-analytical techniques, searching databases such as PubMed, Web of Science, and EMBASE, to gather research on exercise and ghrelin. The quality of the studies was assessed according to the Cochrane Handbook standards, and data analysis for ghrelin, BMI, and weight was performed using RevMan 5.4 and Stata 16.0 software. A total of 13 interventions involving 944 participants were included to systematically investigate the regulatory effects of exercise on ghrelin levels in obese and overweight individuals. Meta-analytical results were calculated using standardized mean differences (SMDs). Results: Exercise interventions significantly increased ghrelin levels (SMD =1.16, 95% CI = 0.52 to 1.80, Conclusion: Prolonged exercise interventions demonstrated a statistically significant effect on ghrelin levels. This indicates that exercise interventions can elevate ghrelin levels, which may be associated with reductions in BMI and weight. Systematic review registration: https://www.crd.york.ac.uk/prospero/, CRD42024588259.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.