ArticlePsychological medicine2025
Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants.
Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Illuminating the complex interplay of risk factors for depression symptoms within a large-scale US longitudinal cohort.Social psychiatry and psychiatric epidemiology · 2026Article
- Exposome and mental health across the lifespan: research and clinical perspectives.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Sex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Exposotypes in psychotic disorders.Scientific reports · 2025Article
- Restoring a Healthy Relationship with Food by Decoupling Stress and Eating: A Translational Review of Nutrition and Mental Health.Nutrients · 2025Review
- Mapping the Exposome of Mental Health Outcomes to Enhance Population Salutogenesis.Alpha psychiatry · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundDissecting the exposome linked to mental health outcomes can help identify potentially modifiable targets to improve mental well-being. However, the multiplicity of exposures and the complexity of mental health phenotypes pose a challenge that requires data-driven approaches.
methodsGuided by our previous systematic approach, we conducted hypothesis-free exposome-wide analyses to identify factors associated with 7 psychiatric diagnostic domains and 19 symptom dimensions in 157,298 participants from the UK Biobank Mental Health Survey. After quality control, 294 environmental, lifestyle, behavioral, and economic variables were included. An Exposome-Wide Association Study was conducted per outcome in two equally split datasets. Variables associated with each outcome were then tested in a multivariable model.
resultsAcross all diagnostic domains and symptom dimensions, the top three exposures were childhood adversities and traumatic events. Cannabis use was associated with common psychiatric disorders (depressive, anxiety, psychotic, and bipolar manic disorders), with ORs ranging from 1.10 to 1.79 in the multivariable models. Additionally, differential associations were identified between specific outcomes-such as neurodevelopmental disorders, eating disorders, and self-harm behaviors-and exposures, including early life experiences (being adopted), lifestyle (time spent using computers), and dietary habits (vegetarian diet).
conclusionsThis comprehensive mapping of the exposome revealed that several factors, particularly in the domains of those previously well-studied were shared across mental health phenotypes, providing further support for transdiagnostic pathoetiology. Our findings also showed that distinct relations might exist. Continued exposome research through multimodal mechanistic studies guided by the transdiagnostic mental health framework is required to better inform public health policies.
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