Evidence map›Paper›PMID 39917921›Full record

ArticleCombinatorial chemistry & high throughput screening2026

CD4

Xiangwen Shi, Linmeng Tang, Mingjun Li, Yipeng Wu, Yongqing Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiangwen ShiDepartment of Orthopedic Surgery, Kunming Medical University, Kunming, Yunnan, China.
Linmeng TangDepartment of Medical Technology, Qujing Medical College, Qujing, Yunnan, China.
Mingjun LiDepartment of Orthopedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, China.
Yipeng WuDepartment of Orthopedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, China.
Yongqing XuDepartment of Orthopedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, China.

Funding

Basic research project of the Science and Technology Department of Yunnan Province 202301AC070621Scientific Research Fund Project of the Department of Education of Yunnan Province 2024Y251Yunnan Clinical Medical Center for Traumatology and Orthopedics ZX20191001Yunnan Orthopedics and Sports Rehabilitation Clinical Medicine Research Center 202102AA310068
6 · The paper itself

Abstract

objectiveWith the accelerated aging of the population, aging has emerged as a major risk factor for osteoporosis (OP). This study aims to investigate the relationship and shared molecular mechanisms between OP and aging through various genetic approaches.

methodsSingle-cell data from the peripheral blood of osteoporosis patients, aging individuals, and healthy controls were integrated to analyze characteristic changes in cell subpopulations. Differentially expressed genes (DEGs) were then identified within core subpopulations, and Mendelian Randomization (MR) analysis was employed to explore potential causal links between key genes and OP. Additionally, an OP model was established in rats, and mRNA levels of key genes were measured using RT-qPCR.

resultsThrough the integration, filtering, and analysis of scRNA-seq data, an increased proportion of CD4

conclusionThis study conducted a comprehensive analysis of the potential link between OP and aging, identifying CD4

Indexed as

AgingCD4-Positive T-LymphocytesMendelian Randomization AnalysisOsteoporosisSingle-Cell AnalysisAnimalsBiomarkersFemaleHumansMaleRatsBiomarkersagingCD4<sup>+</sup> effector memory t cellsmendelian randomizationOsteoporosisRT-qPCRsingle-cell data

Identifiers

PMID39917921

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.