Evidence map›Paper›PMID 39917923›Full record

ArticleCombinatorial chemistry & high throughput screening2026

Yaru Gu, Yaning Biao, Chenxu Liu, Yufang Zhang, Ya Gao, Yucong Xue, Yixin Zhang

Abstract read
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In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaru GuSchool of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China.
Yaning BiaoSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.
Chenxu LiuSchool of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China.
Yufang ZhangSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.
Ya GaoSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.
Yucong XueSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.
Yixin ZhangSchool of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.

Funding

National Natural Science Foundation of China 82003913
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the therapeutic effect of Yueju Pill (YJP) on functional dyspepsia (FD) rats and its mechanism of promoting gastrointestinal motility.

methodsWe replicated FD rat models using classical tail pinching and irregular feeding for 14 days. After 28 days of YJP treatment, we measured the gastric emptying rate and intestinal propulsion rate of the rats. Hematoxylin-eosin (H&E) staining was used to observe the pathological damage in the gastric antrum. The serum levels of related brain-gut peptides (BGPs) were determined using the enzyme-linked immunosorbent assay (ELISA). Furthermore, we detected the expression of proteins related to the SCF/c-Kit/PI3K/AKT signaling pathway through Western blot and immunohistochemistry. Finally, we assessed the levels of apoptosis using the TUNEL assay.

resultsYJP improved gastric emptying and small intestine propulsion rates while reducing gastric tissue injury in FD rats. Moreover, YJP increased the levels of gastrin (GAS) and ghrelin (Ghrelin) and decreased the levels of cholecystokinin (CCK) and vasoactive intestinal peptide (VIP). YJP also elevated the levels of SCF, c-kit and Bcl-2, promoted the phosphorylation of PI3K and AKT, and inhibited the expression of Bax.

conclusionYJP achieved the effect of FD treatment by regulating the SCF/c-Kit/PI3K/AKT pathway, providing a theoretical basis for the clinical treatment of FD.

Indexed as

ApoptosisDrugs, Chinese HerbalDyspepsiaAnimalsMalePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitRatsRats, Sprague-DawleySignal TransductionStem Cell FactorDrugs, Chinese HerbalPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitStem Cell FactorCell apoptosisfunctional dyspepsiaimmunohistochemistry.interstitial cells of CajalTraditional Chinese medicineYueju pill

Identifiers

PMID39917923

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.