Evidence map›Paper›PMID 39918020›Full record

ReviewInternational journal of molecular medicine2025

Importance of STAT3 signaling in preeclampsia (Review).

Daniela Marzioni, Federica Piani, Nicoletta Di Simone, Stefano Raffaele Giannubilo, Andrea Ciavattini, Giovanni Tossetta

Abstract readReview
In one paragraph

Review in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Current Understanding on Hypertensive Disorders in Pregnancy.International journal of general medicine · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Single-cell-level digital twins for preterm birth prevention strategies.bioRxiv : the preprint server for biology · 2025
    Article
  17. Revealing the Complexity of Immunobiological Shifts From Non-Pregnant to Pregnant State.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniela MarzioniDepartment of Experimental and Clinical Medicine, Polytechnic University of Marche, I‑60126 Ancona, Italy.
Federica PianiHypertension and Cardiovascular Risk Research Center, Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, I‑40126 Bologna, Italy.
Nicoletta Di SimoneDepartment of Biomedical Sciences, Humanitas University, I‑20072 Milan, Italy.
Stefano Raffaele GiannubiloDepartment of Clinical Sciences, Polytechnic University of Marche, I‑60123 Ancona, Italy.
Andrea CiavattiniDepartment of Clinical Sciences, Polytechnic University of Marche, I‑60123 Ancona, Italy.
Giovanni TossettaDepartment of Experimental and Clinical Medicine, Polytechnic University of Marche, I‑60126 Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Placentation is a key process that is tightly regulated that ensures the normal placenta and fetal development. Preeclampsia (PE) is a hypertensive pregnancy‑associated disorder characterized by increased oxidative stress and inflammation. STAT3 signaling plays a key role in modulating important processes such as cell proliferation, differentiation, invasion and apoptosis. The present review aimed to analyse the role of STAT3 signaling in PE pregnancies, discuss the main natural and synthetic compounds involved in modulation of this signaling both

Indexed as

Pre-EclampsiaSignal TransductionSTAT3 Transcription FactorAnimalsFemaleHumansPlacentaPregnancySTAT3 protein, humanSTAT3 Transcription FactorcompoundhypoxiainflammationpreeclampsiaSTAT3

Identifiers

PMID39918020
PMCPMC11878484

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.