Evidence map›Paper›PMID 39918201›Full record

ArticleJournal of neurochemistry2025

Genetic Markers of Postmortem Brain Iron.

Marilyn C Cornelis, Amir Fazlollahi, David A Bennett, Julie A Schneider, Scott Ayton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marilyn C CornelisDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-0699-1664
Amir FazlollahiDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
David A BennettRush Alzheimer's Disease Center, Chicago, Illinois, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Chicago, Illinois, USA.
Scott AytonThe Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-3479-2427

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Pathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6M
Neuropathologic-Epidemiological Study of Metallomics and Alzheimer's DiseaseR01AG054057 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Julie A. Schneider · 2022 to 2026
$3.0M
Genetic modifiers of the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) responseR01AG065398 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CORNELIS, MARILYN C · 2020 to 2024
$2.9M
NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG054057NIA NIH HHS R01AG054057NIA NIH HHS R01 AG065398NIA NIH HHS R01AG065398NIA NIH HHS R01AG17917NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG061356NIA NIH HHS U01AG46152NIA NIH HHS U01AG61356
6 · The paper itself

Abstract

Brain iron (Fe) dyshomeostasis is implicated in neurodegenerative diseases. Genome-wide association studies (GWAS) have identified plausible loci correlated with peripheral levels of Fe. Systemic organs and the brain share several Fe regulatory proteins but there likely exist different homeostatic pathways. We performed the first GWAS of inductively coupled plasma mass spectrometry measures of postmortem brain Fe from 635 Rush Memory and Aging Project (MAP) participants. Sixteen single nucleotide polymorphisms (SNPs) associated with Fe in at least one of four brain regions were measured (p < 5 × 10

Indexed as

BrainIronAgedAged, 80 and overAutopsyFemaleGenetic MarkersGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideGenetic MarkersIron

Identifiers

PMID39918201
PMCPMC11804167

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.