Evidence map›Paper›PMID 39918482›Full record

ReviewThe Journal of investigative dermatology2025

Melatonin and the Skin: Current Progress and Perspectives for Human Health.

Andrzej T Slominski, Tae-Kang Kim, Zorica Janjetovic, Radomir M Slominski, Gitali Ganguli-Indra, Mohammad Athar, Arup K Indra, Russel J Reiter, Konrad Kleszczyński

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of investigative dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Melatonin and the Dental Pulp: A Scoping Review.International endodontic journal · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Protective Effect of Melatonin Against Bisphenol A Toxicity.International journal of molecular sciences · 2025
    Review
  10. Review
  11. Review
  12. Review
  13. Review of sensory systems deployed by epidermal keratinocytes.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrzej T SlominskiDepartment of Dermatology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA; Cancer Chemoprevention Program, Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, Alabama, USA; Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, Alabama, USA. Electronic address: aslominski@uabmc.edu.
Tae-Kang KimDepartment of Dermatology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Zorica JanjetovicDepartment of Dermatology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Radomir M SlominskiDepartment of Medicine-Immunology/Rheumatology, The University of Alabama at Birmingham, Birmingham, Alabama, USA; Informatics Institute, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gitali Ganguli-IndraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Mohammad AtharDepartment of Dermatology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA; Pathology and Laboratory Medicine Service, VA Medical Center, Birmingham, Alabama, USA.
Arup K IndraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA; Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
Russel J ReiterDepartment of Cell Systems and Anatomy, Long School of Medicine, UT Health San Antonio, San Antonio, Texas, USA.
Konrad KleszczyńskiDepartment of Dermatology, University of Münster, Münster, Germany. Electronic address: konrad.kleszczynski@ukmuenster.de.

Funding

Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$641k
BLRD VA I01 BX004293NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR056666NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004
6 · The paper itself

Abstract

Skin has the capacity to produce and metabolize melatonin into biologically active metabolites. These metabolites exert phenotypic activities through receptor-dependent and receptor-independent action, including direct antioxidant activity, interaction with regulatory proteins, and regulation of mitochondrial function. They can act on G-protein-coupled melatonin receptors (MT1 and MT2) as well as nuclear aryl hydrocarbon receptor and peroxisome proliferator-activated receptor γ receptors. These metabolic pathways, together with receptor- and nonreceptor-mediated phenotypic activities of its intermediates, has been identified as a cutaneous melatoninergic system. Its pharmacological modulation and topical application of melatonin or its metabolites can be used to prevent and treat skin disorders and cutaneous aging.

Indexed as

MelatoninSkinSkin DiseasesAnimalsAntioxidantsHumansPPAR gammaReceptors, MelatoninSkin AgingAntioxidantsMelatoninPPAR gammaReceptors, MelatoninHuman skinMelatoninMelatonin metabolitesMelatonin receptorsPhotoprotection

Identifiers

PMID39918482
PMCPMC12103292

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.