Observational studyJournal of clinical hypertension (Greenwich, Conn.)2025
Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow-Up Study.
Observational study in Journal of clinical hypertension (Greenwich, Conn.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Uric Acid Serves as a Risk Factor or Marker for Developing Hypertension According to Both Conventional and Novel Definitions: An Association or Causation!Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
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6 authors.
Funding
Abstract
A lower blood pressure threshold (≥130/80 mmHg) to define hypertension has been proposed in several hypertension guidelines. This study assessed the relationship between hyperuricemia and incident hypertension, examining serum uric acid (SUA) cut-offs using both traditional and new definitions in a large Taiwanese cohort. This observational cohort study enrolled 26 973 participants from the Taiwan Biobank (TWB), followed for a median of 4 years. Regarding traditional definition (140/90 mmHg), hyperuricemia (odds ratio [OR], 1.297), quartile 3 of SUA (OR, 1.211), quartile 4 of SUA (OR, 1.495), and high SUA (OR, 1.127) were significantly associated with incident hypertension in males, and hyperuricemia (OR, 1.198), quartile 4 of SUA (OR, 1.359), and high SUA (OR, 1.099) were significantly associated with incident hypertension in females. As for new definition (130/80 mmHg), hyperuricemia (OR, 1.376), quartile 3 of SUA (OR, 1.229), quartile 4 of SUA (OR, 1.554), and high SUA (OR, 1.139) were associated with incident hypertension in males, and hyperuricemia (OR, 1.249), quartile 3 of SUA (OR, 1.253), quartile 4 of SUA (OR, 1.429), and high SUA (OR, 1.096) were associated with incident hypertension in females. The interaction between hyperuricemia and sex on incident hypertension was significant for both traditional (140/90, p < 0.001) and new (130/80, p = 0.001) definitions. Hyperuricemia was significantly associated with incident hypertension under both traditional and new definitions. A significant interaction between hyperuricemia and sex was noted, although the differences were not so great.
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