ArticleJournal of nanobiotechnology2025
Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Comparative evaluation of chitosan-based and star polycation nanocarriers for enhanced RNAi efficacy targeting CmFibL in Cnaphalocrocis medinalis.Pest management science · 2026Article
- Cytochrome P450-mediated regulation of pheromone biosynthesis and adult emergence in Monochamus saltuarius (Coleoptera, Cerambycidae), with implications for pest management.Pest management science · 2026Article
- Review
- Nanoparticle-Mediated RNAi Delivery System Targeting theInsects · 2026Article
- RNA interference in crop protection: opportunities and challenges during the transition to commercialization.Pest management science · 2026Review
- Identification and RNA Interference-Based Functional Analysis of Chitin Deacetylase Genes inInsects · 2026Article
- High-Efficiency and Eco-Friendly Management of Multiple Fungal Diseases by a Novel Carbon Dots sCDP Delivered RNA Nano-Pesticides.Plant biotechnology journal · 2026Article
- Overview of polymeric polyplexes for dsRNA delivery in insects: complexation, stability, and design considerations.Frontiers in insect science · 2026Review
- Screening, optimization and artificial recombination of dsRNA fragments for RNAi-mediated pest resistance inFrontiers in insect science · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundRNA pesticide is regarded as the "third revolution in the history of pesticides". However, the double-stranded RNA (dsRNA) is easily degraded in the environment, and its delivery efficiency is not sufficient for pest management. This study aimed to construct a star polycation (SPc)-based delivery platform with strong protection and efficient delivery to develop a self-assembled RNA pesticide with dual RNA interference (RNAi) targets.
resultsThe nanocarrier SPc was applied to assemble with dsRNA via electrostatic interaction, hydrogen bond and Van der Waals force, and the self-complexation with SPc formed nanoscale dsRNA/SPc complex. The SPc could protect the dsRNA from the degradation by midgut fluid or RNase A, thus significantly increasing the stability of dsRNA under various environmental conditions. Meanwhile, the SPc was able to improve the translocation of dsRNA across insect cuticle, and increase its plant uptake. Then, dsECR-A and dsTre-1 fragments were individually screened, and the dsECR-A and dsTre-1 fragments with good control effects were co-expressed in pET28-BL21 (DE3) RNase III - system to prepare the dsECR-A + Tre-1/SPc complex. Both topical application and spraying of dsECR-A + Tre-1/SPc complex could effectively control a piercing-sucking agricultural pest Apolygus lucorum. The SPc-loaded dsECR-A + Tre-1 could up-regulate endocytosis-related genes and down-regulate cuticle biosynthesis-related genes, which primarily inhibited insect growth and development.
conclusionsOur study comprehensively demonstrated the advantages of SPc-based dsRNA delivery platform, and developed a self-assembled RNA pesticide with dual RNAi targets, which provided a reference for the design of novel RNA pesticides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.