Evidence map›Paper›PMID 39920713›Full record

ArticleBMC endocrine disorders2025

Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway.

Lijing Qin, Rongrong Liu, Zhen Jia, Weiqiang Xu, Li Wang, Hongyuan Tian, Xinru Lian, Wen Li, Yali Qi, Huan He and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lijing Qin *NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Rongrong Liu *NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Zhen JiaNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Weiqiang XuNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Li WangNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Hongyuan TianNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Xinru LianNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Wen LiNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China.
Yali QiJilin Medical University, Jilin, Jilin, 132013, People's Republic of China.
Huan HeNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China. hehuan@jlu.edu.cn.
Zhicheng WangNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, People's Republic of China. zhicheng@jlu.edu.cn.

Funding

Science and Technology Development Plan of Jilin 20240101275JCScience and Technology Development Plan of Jilin YDZJ202201ZYTS153the Science and Technology Development Plan of Jilin YDZJ202401200ZYTS
6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) is the fastest-growing metabolic disease in the world. The gut microbiota is linked to T2DM. Recent studies have showed that the metabolism of gut microbiota can trigger T2DM. Low dose radiation (LDR) has been proved to activate various protective bioeffects on diabetes. However, the underlying mechanisms remain unclear.

methodsIn this study, T2DM model was established using high fat diet combined with streptozocin (STZ) injection in C57BL/6 mice, and then exposed to multiple 75 mGy LDR every other day for one month. The changes of blood glucose levels, body weight, and the damage of pancreas were measured. In addition, 16 S rDNA amplicon sequencing was used to detect gut microbiota alteration. Metabolic profiling was carried out using the liquid mass spectrometry system, followed by the combinative analysis of gut microbiota alteration. Furthermore, the inflammatory factors and related pathways were detected.

resultsWe found that LDR attenuate blood glucose levels and the weights of body in T2DM mice, and reduce pancreas impairment. In addition, in the gut, LDR regulated the relative abundance of Bacilli, Desulfobacterota, Verrucomicrobiota, and Proteobacteria. The non-target metabolomics analysis found that LDR significantly improve the metabolic abnormalities in T2DM, which is closely related to the gut microbiota abundance. Furthermore, the inflammatory effects activated by TLR4/MyD88/NF-κB pathways in T2DM were ameliorated by LDR.

conclusionThese results suggest that LDR may exert a beneficial role in T2DM by modulating gut microbiota and metabolites, especially in TLR4/MyD88/NF-κB pathway.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeMyeloid Differentiation Factor 88NF-kappa BToll-Like Receptor 4AnimalsMaleMiceMice, Inbred C57BLSignal TransductionMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseToll-Like Receptor 4Gut microbiotaLow dose radiationMetabolitesToll-like receptor 4Type 2 diabetes mellitus

Identifiers

PMID39920713
PMCPMC11804101

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.