Evidence mapPaperPMID 39921221Full record

ReviewAnimal models and experimental medicine2025

Bird's eye view of natural products for the development of new anti-HIV agents: Understanding from a therapeutic viewpoint.

Md Al Amin, Mohamed H Nafady, Mehrukh Zehravi, Sherouk Hussein Sweilam, Kusuma Praveen Kumar, M Akiful Haque, Aziz Unnisa, Laliteshwar Pratap Singh, Mohammed Sayeed, Mohammed Ali Alshehri and 3 more

Abstract readReview
In one paragraph

Review in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Md Al AminDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, Bangladesh.
Mohamed H NafadyFaculty of Applied Health Science Technology, Misr University for Science and Technology, Giza, Egypt.
Mehrukh ZehraviDepartment of Clinical Pharmacy, College of Dentistry & Pharmacy, Buraydah Private Colleges, Buraydah, Saudi Arabia.
Sherouk Hussein SweilamDepartment of Pharmacognosy, Faculty of Pharmacy, Egyptian Russian University, Badr, Egypt.
Kusuma Praveen KumarDepartment of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University (DPSRU), Govt. of N.C.T. of Delhi, New Delhi, India.
M Akiful HaqueDepartment of Pharmaceutical Analysis, School of Pharmacy, Anurag University, Hyderabad, India.
Aziz UnnisaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, Saudi Arabia.
Laliteshwar Pratap SinghDepartment of Pharmaceutical Chemistry, Narayan Institute of Pharmacy, Gopal Narayan Singh University, Sasaram (Rohtas), Bihar, India.
Mohammed SayeedDepartment of Pharmacology, School of Pharmacy, Anurag University, Hyderabad, Telangana, India.
Mohammed Ali AlshehriDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Irfan AhmadDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Talha Bin EmranDepartment of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, Bangladesh.
Md Zia UddinDepartment of Pharmacy, Faculty of Pharmaceutical Sciences, University of Science and Technology Chittagong, Chattogram, Bangladesh.ORCID 0000-0002-0606-0966

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired immune deficiency syndrome (AIDS) is the name used to describe several potentially life-threatening infections and disorders that happen when HIV has severely compromised the immune system. The primary effect of HIV is to decrease host immunity, exposing the host to external pathogens. The development of pharmaceutical drugs that directly cure the infection is crucial because of the current wide-ranging epidemic of HIV. Most therapeutic anti-HIV drugs are nucleosides. However, their high toxicity and potential for drug resistance restrict their use. Many of the most effective clinical drugs used to inhibit HIV, the activation of latent HIV, and AIDS have been obtained from natural sources. This review focuses on potential natural medicinal products for treating and managing HIV and AIDS. Notwithstanding, further clinical research studies are needed to understand the subject and its dynamics.

Indexed as

Anti-HIV AgentsBiological ProductsHIV InfectionsAcquired Immunodeficiency SyndromeAnimalsDrug DevelopmentHumansAnti-HIV AgentsBiological ProductsAIDSanti‐HIV agentsHIVimmune systemmarine compoundsnatural productsphytoconstituents

Identifiers

PMID39921221
PMCPMC11904116

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.