Evidence map›Paper›PMID 39921737›Full record

ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2025

Histone acetyltransferase Sas3 in Phomopsis liquidambaris promotes spermidine biosynthesis against Fusarium graminearum in wheat.

Xinru Cui, Zhi Yang, Longshen Wang, Yuxin Dong, Sitong Ke, Zhichun Zhan, Chuanchao Dai, Yanzhen Mei

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Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinru CuiJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China.
Zhi YangWuhan Sunhy Biology Co., Ltd., Wuhan, 430000, Hubei, China.
Longshen WangJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China.
Yuxin DongJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China.
Sitong KeJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China.
Zhichun ZhanWuhan Sunhy Biology Co., Ltd., Wuhan, 430000, Hubei, China.
Chuanchao DaiJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China.
Yanzhen MeiJiangsu Key Laboratory for Pathogens and Ecosystems, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, Jiangsu Province, China. meiyanzhen@njnu.edu.cn.ORCID http://orcid.org/0000-0001-7988-626X

Funding

National Natural Science Foundation of China Grant No. 32070058
6 · The paper itself

Abstract

key messageSpermidine production in the endophytic fungus Phomopsis liquidambaris is regulated by Sas3, and spermidine promotes resistance to Fusarium graminearum by increasing the expression of immune-related indicators in wheat. Fusarium head blight (FHB) is a common wheat disease caused mainly by Fusarium graminearum. The present study showed that overexpression of the histone acetyltransferase Sas3 in Phomopsis liquidambaris regulated the synthesis of spermidine and promoted resistance to F. graminearum in wheat. Sas3 localized in the nucleus plays a key role in acetylating lysines 9 and 14 of histone H3 (H3K9 and H3K14) and clearly promotes the development and growth of P. liquidambaris in the overexpression strain OE-Sas3 and knockout strain Ko-Sas3. The OE-Sas3 strain promoted the growth of wheat seedlings and increased the level of reactive oxygen species (ROS) pumps, which increased the activities of the catalase (CAT) and peroxidase (POD) and the expression levels of genes involved in the jasmonic acid, ethylene, and salicylic acid pathways. Furthermore, OE-Sas3 increased the level of resistance of wheat to F. graminearum through the positive regulation of spermidine biosynthesis, which reduced the incidence of wheat spike disease from 76 to 54% and that of grain disease from 52.35 to 32.68%. This study provides a new perspective for the application of P. liquidambaris as a biocontrol agent via rational design and improved FHB resistance.

Indexed as

AscomycotaDisease ResistanceFusariumHistone AcetyltransferasesPlant DiseasesPlant ProteinsSpermidineTriticumGene Expression Regulation, PlantReactive Oxygen SpeciesHistone AcetyltransferasesPlant ProteinsReactive Oxygen SpeciesSpermidine

Identifiers

PMID39921737

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.