Evidence map›Paper›PMID 39922928›Full record

ArticleScientific reports2025

Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study.

Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lorena González *Fundació Institut Germans Trias i Pujol, Barcelona, E-08916, Spain.
Carolina Gonzalez-Riano *Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Pablo Fernández-GarcíaDepartment of Basic Health Sciences, University Rey Juan Carlos (URJC), Campus Alcorcón, Madrid, E-28922, Spain.
Rubén CereijoDepartament of Biochemistry and Molecular Biomedicine, and Institut de Biomedicina (IBUB), University of Barcelona, Barcelona, Spain.
Aina VallsPediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona, E-08916, Spain.
Andrea Soria-GondekPediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona, E-08916, Spain.
Nativitat RealPediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona, E-08916, Spain.
Belén RequenaCentro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Joan Bel-ComosPediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona, E-08916, Spain.
Patricia CorralesDepartment of Basic Health Sciences, University Rey Juan Carlos (URJC), Campus Alcorcón, Madrid, E-28922, Spain.
David Jiménez-PavónMOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain.
Coral BarbasCentro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Boadilla del Monte, 28660, Spain.
Francesc VillarroyaDepartament of Biochemistry and Molecular Biomedicine, and Institut de Biomedicina (IBUB), University of Barcelona, Barcelona, Spain.
David Sánchez-InfantesDepartment of Basic Health Sciences, University Rey Juan Carlos (URJC), Campus Alcorcón, Madrid, E-28922, Spain. david.sanchezi@urjc.es.
Marta MurilloPediatric Department, Hospital Universitari Germans Trias i Pujol, Badalona, E-08916, Spain. mmurillo.germanstrias@gencat.cat.

Funding

Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable CB16/10/00477European Commission Project 101079938European Regional Development Fund PID 2021-122490NB-I00Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033
6 · The paper itself

Abstract

Recombinant human growth hormone (rhGH) therapy is the primary treatment for children born small for gestational age (SGA) who fail to show spontaneous catch-up growth by two or four years. While its effects on white adipose tissue are well-documented, this pilot study aimed to investigate its impact on the lipidome and the thermogenic and endocrine activities of brown adipose tissue (BAT) in SGA children following rhGH treatment. The study involved 11 SGA children divided into two groups: (a) SGA children who were not treated with rhGH (n = 4) and (b) SGA children who received rhGH treatment with Saizen

Indexed as

Adipose Tissue, BrownHuman Growth HormoneInfant, Small for Gestational AgeLipid MetabolismLipidomicsBiomarkersChildChild, PreschoolFemaleHumansInfant, NewbornMalePilot ProjectsRecombinant ProteinsBiomarkersHuman Growth HormoneRecombinant ProteinsBrown adipose tissueLipidomeRecombinant human growth hormoneSmall for gestational age

Identifiers

PMID39922928
PMCPMC11807155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.