Evidence map›Paper›PMID 39922997›Full record

Trial reportBMC public health2025

A pilot cluster randomized controlled trial assessing uptake of PrEP and contraception in hair salons in South Africa.

Ingrid V Bassett, Joyce Yan, Sabina Govere, Sthabile Shezi, Lungile M Ngcobo, Shruti Sagar, Jana Jarolimova, Dani Zionts, Anele Khumalo, Zinhle Zwane and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04222504 (Community-based Venues for Delivery of Healthcare Services in Umlazi, South Africa), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04222504 nacompletednot on this map

Community-based Venues for Delivery of Healthcare Services in Umlazi, South Africa: Proof of Concept Pilot Conducted in Hair Salons

TypeinterventionalSponsorMassachusetts General HospitalRan2021 to 2026Enrolled436ConditionsPre-Exposure Prophylaxis, STI, Contraceptive UsageArmsProvision of sexual health preventative services in the salon setting
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ingrid V BassettDivision of Infectious Diseases, Massachusetts General Hospital, 100 Cambridge Street, 16th Floor, Boston, MA, 02114, USA. ibassett@mgh.harvard.edu.
Joyce YanBiostatistics Center, Massachusetts General Hospital, Boston, MA, USA.
Sabina GovereAIDS Healthcare Foundation, Durban, South Africa.
Sthabile SheziAIDS Healthcare Foundation, Durban, South Africa.
Lungile M NgcoboAIDS Healthcare Foundation, Durban, South Africa.
Shruti SagarMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Jana JarolimovaDivision of Infectious Diseases, Massachusetts General Hospital, 100 Cambridge Street, 16th Floor, Boston, MA, 02114, USA.
Dani ZiontsMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Anele KhumaloAIDS Healthcare Foundation, Durban, South Africa.
Zinhle ZwaneAIDS Healthcare Foundation, Durban, South Africa.
Christina PsarosHarvard Medical School, Boston, MA, USA.
Nduduzo DubeAIDS Healthcare Foundation, Durban, South Africa.
Robert A ParkerCenter for AIDS Research (CFAR), Harvard University, Boston, MA, USA.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Mentoring in patient-oriented research on HIV prevention in the US and South AfricaK24AI141036 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Ingrid Valerie Bassett · 2019 to 2026
$1.1M
Screening strategies for sexually transmitted infections in a high HIV incidence setting in South AfricaK23AI174917 · NIAID · MIRIAM HOSPITAL · PI Jana Jarolimova · 2023 to 2026
$770k
Harvard University Center for AIDS Research P30AI060354NIAID NIH HHS K23 AI174917NIAID NIH HHS K24 AI141036NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007433NIH HHS K24AI141036NIH HHS T32AI007433
6 · The paper itself

Abstract

backgroundWomen in South Africa have a high burden of HIV infections, STIs, and unintended pregnancies. Women congregate regularly in hair salons, which may be useful venues for HIV and sexual and reproductive health (SRH) services. Our objective was to assess the uptake of PrEP and contraception in hair salons in South Africa.

methodsWe conducted a pilot cluster randomized controlled trial to evaluate uptake of a hair stylist-initiated, nurse-supported intervention offering a dynamic choice of contraception (oral or injectable), STI testing and treatment, and oral PrEP in 3 salons in urban KwaZulu-Natal. Rapid HIV testing was performed in a private area at enrollment and each PrEP dispensing. Women could receive contraception and/or oral PrEP at the initial visit or opt in at a later visit. We defined uptake as the proportion of eligible women who accepted salon-based PrEP and/or salon-based contraception at any visit. Control salon participants completed surveys and were referred to clinic. We assessed predictors of PrEP uptake among intervention participants using univariate logistic regression and multivariable logistic regression with age and potential predictors from the univariate analyses.

resultsAmong 134 participants in intervention salons, the median age was 26 years (IQR 22-29). 75% reported visiting the salon at least every 2 months. 27% were using hormonal contraception at enrollment, 31% reported a self-perceived moderate or great chance of getting HIV in the next year, 33% thought their primary sex partner had other partners, 65% did not use condoms in the past month, and 11% reported intimate partner violence (IPV). About half (49%) accepted salon-based PrEP, and 89% accepted salon-based contraception during the study. Adjusting for age, uptake of salon-based PrEP was associated with experiencing IPV (aOR 4.20, 95%CI: 1.02, 17.36).

conclusionsWhen offering a dynamic choice of integrated SRH services in urban hair salons in South Africa, we reached young women with risk factors for HIV, STIs, and unintended pregnancies. Hair salons are a novel venue for reaching young women who may not perceive themselves at risk for HIV, STIs, and unintended pregnancies.

trial registrationClinicaltrials.gov identifier: NCT04222504. Registered 01-08-2020.

Indexed as

ContraceptionHIV InfectionsPatient Acceptance of Health CarePre-Exposure ProphylaxisAdolescentAdultFemaleHumansPilot ProjectsSouth AfricaYoung AdultCommunity health servicesContraceptionPre-exposure prophylaxisSexually transmitted diseasesSouth Africa

Identifiers

PMID39922997
PMCPMC11806743

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.