ArticleScientific reports2025
The long-term associations of childhood parental loss with attachment, creativity, and epigenetic regulation.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evaluating potential effect of adverse childhood experiences on depressive symptoms in Chinese middle-aged and older adults: a simulation-based network analysis.BMC psychology · 2026Article
- Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics.Frontiers in psychiatry · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The loss of a parent during childhood is a profound event with enduring impacts on psychological and emotional development. This study investigates the long-term effects of childhood parental loss on attachment patterns and openness to experience, with a focus on the epigenetic modulation of the oxytocin and dopamine systems. The sample included 371 participants (51.2% women, ages 26-43), of whom 33 experienced parental loss during childhood. In those individuals who lost a parent, findings revealed comparably lower attachment avoidance and a DNA methylation profile associated with a potential for increased oxytocin activity. Additionally, a DNA methylation profile associated with a potential for heightened dopamine activity was identified in this group, aligning with greater creativity. These findings highlight the intricate interplay of genetic and environmental factors in fostering resilience and personal growth, shedding light on the roles of oxytocin and dopamine in social bonding and the potential for long-term adaptation following early-life trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.