Evidence mapPaperPMID 39924729Full record

ArticleProteomics2025

Clinical Proteomics, Quo Vadis?

Harald Mischak, Joost P Schanstra, Antonia Vlahou, Joachim Beige

Abstract read
In one paragraph

Article in Proteomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Harald MischakMosaiques Diagnostics GmbH, Hannover, Germany.ORCID 0000-0003-0323-0306
Joost P SchanstraInstitute of Cardiovascular and Metabolic Disease, U1297, Institut National de la Santé et de la Recherche Médicale, Toulouse, France.ORCID 0000-0002-7471-372X
Antonia VlahouCenter of Systems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.ORCID 0000-0003-3284-5713
Joachim BeigeMartin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID 0000-0002-1907-825X

Funding

Accurate-CVD ZIM-KK5560002AP3Agence nationale de la recherché ANR-22-PERM-0002-06DC-ren project, European Union's Project 101097094Doctoral Networks Programme PICKED 101168626Doctoral Networks Programme PICKED HORIZON-MSCA-2023-DN-01ERA PerMed SIGNAL project 01KU2307European Cooperation in Science and Technology CA21165European Union's Horizon 2020 research and innovation programme under 848011European Union's Horizon Europe Marie Skłodowska-Curie Actions Doctoral Networks -Industrial Doctorates Programme DisCo-I 101072828European Union's Horizon Europe Marie Skłodowska-Curie Actions Doctoral Networks -Industrial Doctorates Programme DisCo-I HORIZON-MSCA-2021-DNGerman ministry foreducation and science (BMBF) via UPTAKE 01EK2105BGerman ministry foreducation and science (BMBF) via UPTAKE 01EK2105C
6 · The paper itself

Abstract

The field of clinical proteomics has seen enormous growth in the past 20 years, with over 40,000 scientific manuscripts published to date. At the same time, actual clinical application of the reported findings is obviously scarce. In this viewpoint article, we discuss the key issues that may be responsible for this apparent lack of success. We conclude that success must not be assessed based on the number of publications, but via the impact on patient management and treatment. We proceed with specific suggestions for potential solutions, which include keeping a strict focus on potential patient benefit. We hope this article can help shape the field, so it can in fact deliver on its realistic promise to bring significant improvement in management and care to patients.

Indexed as

ProteomicsHumansclinical proteomicsclinical studyimplementationpatient benefit

Identifiers

PMID39924729
PMCPMC11962580

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.