SynthesisBrain and behavior2025
Relationship Between Sleep Disturbances and In Vitro Fertilization Outcomes in Infertile Women: A Systematic Review and Meta-Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sleep disturbances and assisted reproduction outcomes in women undergoing IVF/ICSI: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Melatonin improved the outcomes of women with ART: a systematic review and meta-analysis of randomized trials.Frontiers in reproductive health · 2025Pooled it
- Sleep Disruption and Shift Work Associate with Increased Risk of Reproductive Endocrine Disorders: Evidence from UK Biobank and Mendelian Randomization.International journal of women's health · 2026Article
- Determining the relationship between sleep quality and reproductive health issues in fertile and infertile men and women: A cross-sectional study.Sleep medicine: X · 2025Article
- A Cohort Study on Factors Affecting Sleep Quality in Women Undergoing Intrauterine Sperm Insemination (IUI) Treatment.Obstetrics and gynecology international · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn vitro fertilization (IVF) has been acknowledged as the primary assisted reproductive technique for fertilizing oocytes outside the female reproductive system. Sleep disorders are likely to affect infertility and its treatment. The present study was to investigate the relationship between sleep disturbances and IVF outcomes in infertile women.
methodsDatabases, including PubMed, Embase, Cochrane Library, ProQuest, and Web of Science, were searched for the relevant articles published up to September 2023. The Newcastle-Ottawa Scale was used to assess the methodological quality of the included studies. Moreover, the random and fixed effects models using the STATA (v.11) software program presented the odds ratio with a 95% confidence interval (CI). Ultimately, a funnel plot was recruited to examine the sensitivity analysis.
resultsDuring the initial search, 426 articles were retrieved, and ultimately, nine studies remained for systematic review, and among them, four studies entered into the meta-analysis (two cohort and two cross-sectional studies). According to the fixed effects model of the cross-sectional studies, the association between sleep quality and pregnancy rate was not confirmed (OR = 0.94; 95% CI = 0.81-1.07). Regarding the fixed effects model of included cohort studies, the results indicated an association between sleep quality and the pregnancy rate (OR = 1.08; 95% CI = 1.03-1.14). According to the random effects model of the cross-sectional studies, there was no significant association between sleep quality and pregnancy rate (OR = 0.82; 95% CI = 0.37-1.26). Regarding the random effect analysis of included cohort studies, the results indicated an association between sleep quality and the pregnancy rate (OR = 1.08; 95% CI = 1.03-1.14). Based on the total fixed effect analysis of the cross-sectional and cohort studies, the results also showed a significant association between sleep quality and pregnancy rate among infertile women (OR = 1.06; 95% CI = 1.01-1.11). In contrast, according to the random effect of the total studies, this association was not confirmed (OR = 1.02; 95% CI = 0.90-1.14).
conclusionAlthough the meta-analysis of the cohort studies showed a significant association between sleep quality and IVF outcomes, such as pregnancy rate, due to the novelty of the subject, more studies have not been published, and this study is considered a preliminary meta-analysis. Therefore, more studies with a strong methodology need to assess the relationship between sleep disorders and IVF outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.