ArticleFrontiers in public health2025
Association of biochemical indicators with multimorbidity in 19,624 older adult individuals with chronic diseases: a study from Jindong District, Jinhua City, China.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of digital health interventions on glycaemic control among type 2 diabetes individuals in low and middle-income countries: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Serum uric acid, gout, cardiometabolic diseases, and multimorbidity: a prospective cohort study using multi-state model.npj aging · 2026Article
- Oral Health, Inflammation, and the Burden of Multiple Long-Term Conditions: Cross-Sectional Analyses from UK Biobank and NHANES.Journal of clinical medicine · 2026Article
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Abstract
Background: Chronic disease multimorbidity is influenced by multiple factors, but with little knowledge on the impact of biochemical indicators. This study aims to investigate the prevalence of multimorbidity of chronic diseases among older adult individuals in the community, as well as the factors related to biochemical indicators associated with chronic disease multimorbidity. Methods: The study included 19,624 older adult individuals aged 60 and above in Jindong District, Jinhua City, Zhejiang Province, China. Participants completed a national standardized older adult health examination in the community. Chi-square tests and logistic regression were employed to evaluate the potential factors of biochemical indicators related to multimorbidity of chronic diseases. Results: The multimorbidity rate of chronic diseases in older adult patients is 70.3%. Each chronic disease coexists with one or more other chronic diseases in over 75% of cases. Among the biochemical indicators, hemoglobin (Hb) (OR = 1.46, 95%CI: 1.13-1.90), white blood cell count (WBC) (OR = 1.25, 95%CI: 1.02-1.54), red blood cell count (RBC) (OR = 1.36, 95%CI: 1.10-1.69), urinary protein (U-PRO) (OR = 1.10, 95%CI: 1.02-1.19), urinary glucose (U-GLU) (OR = 1.44, 95%CI: 1.23-1.67), alanine aminotransferase (ALT) (OR = 1.71, 95%CI: 1.39-2.10), aspartate aminotransferase (AST) (OR = 1.22, 95%CI: 1.05-1.41), creatinine (Cr) (OR = 1.28, 95%CI: 1.16-1.42), uric acid (UA) (OR = 1.36, 95%CI: 1.22-1.51), total cholesterol (TC) (OR = 1.76, 95%CI: 1.59-1.95), triglycerides (TG) (OR = 2.63, 95%CI: 2.46-2.82), low-density lipoprotein cholesterol (LDL-C) (OR = 1.84, 95%CI: 1.60-2.11), high-density lipoprotein cholesterol (HDL-C) (OR = 10.99, 95%CI: 8.12-14.90), and fasting blood glucose (FBG) (OR = 1.89, 95%CI: 1.74-2.05) are associated with the risk of multimorbidity of chronic diseases ( Conclusion: This study found that the prevalence of multimorbidity among older adult individuals in this region reached 70.3%. Multiple biochemical indicators were significantly associated with multimorbidity, particularly lipid parameters (low HDL-C and elevated TG), glucose parameters (elevated FBG and positive U-GLU), liver function (elevated ALT), and hemoglobin levels. These findings provide important evidence for research on factors associated with multimorbidity in the older adult population.
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