ArticleCurrent opinion in behavioral sciences2025
Neurostimulation to Improve Cognitive Flexibility.
Article in Current opinion in behavioral sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Task-guided accelerated cTBS simultaneously treats depression and social dysfunction in patients with major depressive disorder: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement.bioRxiv : the preprint server for biology · 2025Article
- Cingulate-centered flexible control: physiologic correlates and enhancement by internal capsule stimulation.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cognitive flexibility, the capacity to adapt behaviors in response to changing environments, is impaired across mental illnesses, including depression, anxiety, addiction, and obsessive-compulsive disorder. Cortico-striatal-cortical circuits are integral to cognition and goal-directed behavior and disruptions in these circuits are linked to cognitive inflexibility in mental illnesses. We review evidence that neurostimulation of these circuits can improve cognitive flexibility and ameliorate symptoms, and that this may be a mechanism of action of current clinical therapies. Further, we discuss how animal models can offer insights into the mechanisms underlying cognitive flexibility and effects of neurostimulation. We review research from animal studies that may, if translated, yield better approaches to modulating flexibility. Future research should focus on refining definitions of cognitive flexibility, improving detection of impaired flexibility, and developing new methods for optimizing neurostimulation parameters. This could enhance neurostimulation therapies through more personalized treatments that leverage cognitive flexibility to improve patient outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.