ArticleJournal of inflammation research2025
Exploring Inflammatory Changes in the Peripheral Blood of Type 2 Diabetes Mellitus in China.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Serum copper modulates cognitive function in diabetic patients via an HDL-C-mediated pathway: identification of a 25 µg/dL exploratory threshold.Diabetology & metabolic syndrome · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Objective: Type 2 diabetes mellitus (T2DM) is a serious, chronic metabolic disease globally and its pathogenesis is not completely understood yet. This study aimed to thoroughly investigate the fluctuation of inflammatory markers in the peripheral blood of patients with T2DM, which are rarely reported. Methods: Peripheral blood samples from patients with T2DM and healthy individuals, as well as their clinical information, were collected at the Second Affiliated Hospital of Soochow University. Flow cytometry was used to analyse the immune cells and cytokines in the peripheral blood. CCK-8 assay was performed to detect the viability of THP-1 cell after treatment with 5 mΜ or 50 mΜ glucose. Flow cytometry, Western Blotting and qPCR were used to analyse the apoptosis of monocytes or THP-1 cells. Results: The numbers of white blood cells, lymphocytes, and neutrophils substantially increased with elevated IL-6 levels. There was a significant decrease in monocytes due to increased cell apoptosis caused by sustained high glucose stimulation. Hyperglycemia reduced monocyte viability and altered monocyte subgroups by increasing the number of intermediate and non-classical monocytes. Conclusion: In summary, our work reveals that patients with T2DM do have variations of peripheral inflammation biomarkers, especially monocytes.
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