ArticleACS omega2025
Chiral Recognition Mechanism of Amlodipine by Capillary Electrophoresis Using Carboxymethyl-β-cyclodextrin: An Experimental and Theoretical Study.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A computational study on the enantioselective separation of cyhalothrin enantiomers by β-cyclodextrins.Journal of molecular modeling · 2025Article
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Authors and funding
3 authors.
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Abstract
Chiral capillary electrophoresis (CCE) represents an effective technique for enantioselective separations. However, additional techniques may be necessary to determine the enantiomers migration order (EMO) and elucidate the chiral recognition mechanism. This study details the development and optimization of a CCE method for the enantioseparation of amlodipine (AML). Furthermore, it contributes computationally to determining the EMO and the mechanisms responsible for chiral discrimination. The study proposed the optimization of several key parameters in CCE, including the type, concentration and pH of the background electrolyte, as well as the concentration of the chiral selector. In line with previous research, only one anionic cyclodextrin, carboxymethyl-β-cyclodextrin (CM-β-CD), was evaluated as the chiral selector. Following optimization, the most favorable results were achieved using 50 mM phosphate background electrolyte pH 4.0 with 2.5 mg mL
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Registered trials
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