SynthesisMedicine2025
Association of type 2 diabetes with osteoporosis and fracture risk: A systematic review and meta-analysis.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Association of central adiposity and metabolic markers with osteopenia and osteoporosis in Chinese adults: a QCT-based cross-sectional study.Scientific reports · 2026Article
- Cuproptosis and Diabetic Osteoporosis: Mechanisms and Therapeutic Prospects.International journal of molecular sciences · 2026Review
- Serum 25-hydroxyvitamin D is associated with islet function in postmenopausal women with type 2 diabetes and osteoporosis.Frontiers in endocrinology · 2026Article
- Article
- Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors.World journal of diabetes · 2025Review
- 10-Year Fracture Risk Assessment with Novel Adjustment (FRAXplus): Type 2 Diabetic Sample-Focused Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo.Archives of pharmacal research · 2025Article
- Top comorbidities in osteoporotic fracture patients in a northeast population in China.BMC public health · 2025Article
- The status and trends of type 2 diabetic osteoporosis research: a global bibliometric and visualization analysis over the past 20 years.Frontiers in clinical diabetes and healthcare · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis, a systemic skeletal disease characterized by low bone mass and increased fracture risk, poses significant social and economic challenges globally, while type 2 diabetes mellitus (T2DM), a prevalent metabolic disorder, has been linked to complex effects on bone health, including contradictory findings on its relationship with osteoporosis and fracture risk.
methodsWe searched PubMed, Embase, Cochrane, and Web of Science Library to identify observational studies investigating whether people with T2DM have a higher risk of osteoporosis or fracture than people without diabetes. The time limit for literature retrieval was from the establishment of the database until March 2023. The quality of the studies was assessed using the Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality checklist. The meta-analysis was conducted using Stata 15, and a random-effects model was used if I2 was > 50%. The Egger test was used to assess publication bias.
resultsThe results demonstrated that people with T2DM have a higher risk of osteoporosis. (relative risk, 1.841; 95% confidence interval, 1.219-2.780; P = .004). Similar results were demonstrated for fractures (relative risk, 1.21; 95% confidence interval, 1.09-1.31; P < .001). However, the results of the subgroup analysis showed no significant correlation between T2DM and fractures in univariate analysis, cross-sectional studies, Asia, Europe, Oceania, and vertebral fractures. However, a significant correlation was found in other subgroup analyses.
conclusionsOsteoporosis and fractures are significantly associated with T2DM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.