Evidence map›Paper›PMID 39929057›Full record

ArticleDrug and alcohol dependence2025

Effects of alcohol and cannabis co-use on salience network resting state functional connectivity in individuals who drink alcohol heavily.

Kaitlin R McManus, Malia Belnap, Dylan E Kirsch, Lara A Ray, Erica N Grodin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaitlin R McManusDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States.
Malia BelnapDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States; Neuroscience Interdepartmental Program, University of California at Los Angeles, Los Angeles, CA, United States.
Dylan E KirschDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States.
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, United States; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States. Electronic address: lararay@psych.ucla.edu.
Erica N GrodinDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, United States; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

A Randomized Controlled Clinical Trial of the Neuroimmune Modulator Ibudilast for the Treatment of Alcohol Use DisorderR01AA026190 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2018 to 2021
$2.7M
Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)T32HD091059 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mirella Dapretto, ANDREW J FULIGNI · 2018 to 2026
$1.7M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use DisorderK01AA029712 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Erica N Grodin · 2022 to 2026
$819k
The effects of stress on decision-making in alcohol use disorder: A translational approachR21AA030643 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2023 to 2024
$410k
A clinical neuroscience approach to understand stress coping in alcohol use disorderF32AA031425 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIRSCH, DYLAN E · 2024 to 2024
$32k
NIAAA NIH HHS F32 AA031425NIAAA NIH HHS K01 AA029712NIAAA NIH HHS K24 AA025704NIAAA NIH HHS R01 AA026190NIAAA NIH HHS R21 AA030643NICHD NIH HHS T32 HD091059
6 · The paper itself

Abstract

introductionThe salience network may be linked to addiction. Evidence suggests less salience network resting state functional connectivity (rsFC) from heavy alcohol use, but higher rsFC within and between brain networks from regular cannabis use. Given the rise in alcohol-cannabis co-use, the present study sought to elucidate rsFC between regions within the salience network and regions across the whole brain in individuals who use no drugs regularly, those who use alcohol only heavily, and those who co-use alcohol-cannabis.

methodsThis is a secondary analysis of three clinical laboratory studies. A total of sixty individuals were classified into one of three groups based on their drug use: control (n = 16), heavy alcohol use only (n = 27), and heavy alcohol and regular cannabis co-use (n = 17). All participants completed resting state fMRI scans. Seed regions from the salience network were used to examine group differences in rsFC.

resultsMain effects of group on rsFC emerged between the anterior cingulate cortex, left and right anterior insula, and left supramarginal gyrus seeds and regions associated with motor, sensory, visual, and executive control functioning (all ps < 0.05). Post-hoc analyses revealed less rsFC between alcohol-only and co-use groups as compared to controls (all ps < 0.05), but no differences between alcohol-only and co-use groups (all ps > 0.05).

conclusionsThis preliminary study suggests that co-using alcohol-cannabis may not be associated with any additive or contrasting effects on rsFC compared to using alcohol alone. Thus, in individuals who co-use alcohol-cannabis, alcohol may drive neural alterations associated with inhibitory control and substance craving.

Indexed as

Alcohol DrinkingAlcoholismBrainMarijuana AbuseMarijuana UseNerve NetAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysYoung AdultAlcoholCannabisCo-useResting stateSalience network

Identifiers

PMID39929057
PMCPMC13011813

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.