Evidence map›Paper›PMID 39930171›Full record

ArticleAdvances in experimental medicine and biology2025

The BXD32 Mouse: A High-Fidelity Model of Chronic Retinal Inflammation and Photoreceptor Degeneration.

T J Hollingsworth, Bahar Meshkat, Xiangdi Wang, William A White, Esther Marquez-Wilkins, Monica M Jablonski

Abstract read
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Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

T J HollingsworthDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA. thollin1@uthsc.edu.
Bahar MeshkatDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA.
Xiangdi WangDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA.
William A WhiteDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA.
Esther Marquez-WilkinsDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Monica M JablonskiDepartment of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of retinal degenerations (RDs) is a field involving all aspects of retinal anatomy, physiology, and genetics. RDs are heterogeneous involving many genes and systems underlying their pathogeneses. To understand these processes, animal models act as surrogates for human studies; however, an ever-existent issue is few models offer high-fidelity and direct correlations to the human condition. Our recent work has established an animal model that is able to fill both needs. The BXD32 mouse exhibits a polygenic inherited retinal dystrophy (IRD) that correlates to human disease through aberrant disc formation and chronic retinal inflammation working in concert with the genetic underliers to advance the disease. This model can serve to test anti-inflammatory treatments directly to affected tissue avoiding systemic issues as well as understanding the pathophysiology of human IRDs.

Indexed as

Disease Models, AnimalPhotoreceptor Cells, VertebrateRetinal DegenerationRetinitisAnimalsChronic DiseaseHumansInflammationMiceAnimal modelsCone-rod dystrophyInflammationInherited retinal dystrophyNf-κBNLRP3Polygenic diseaseRetinal degenerationsRod-cone dystrophyTNFα

Identifiers

PMID39930171

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.