Evidence map›Paper›PMID 39930242›Full record

ReviewAdvances in experimental medicine and biology2025

Targeting Connexins Biology as Therapeutic Strategies Against Retinal Diseases.

Alicia Domenech-Bendaña, Nicolle Salazar, Antonella Locascio, Alejandro Ponce-Mora, Lucía Gimeno-Mallench, Eloy Bejarano

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alicia Domenech-BendañaSchool of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Moncada, Valencia, Spain.
Nicolle SalazarSchool of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Moncada, Valencia, Spain.
Antonella LocascioSchool of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Moncada, Valencia, Spain.
Alejandro Ponce-MoraSchool of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Moncada, Valencia, Spain.
Lucía Gimeno-MallenchSchool of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Moncada, Valencia, Spain.
Eloy BejaranoSchool of Health Sciences and Veterinary School, Universidad CEU Cardenal Herrera, CEU Universities, Moncada, Valencia, Spain. eloy.bejaranofernandez@uchceu.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gap junctions are intercellular channels formed by structural elements called connexins. These intercellular channels play a key role in retinal homeostasis by enabling the exchange of metabolites between neighbouring cells. Several connexins are expressed in different retinal cells, suggesting that the permeability properties of the channels and their physiological relevance could be cell-type dependent. Many studies have revealed that dysfunctional gap junction activity contributes to the development and worsening of retinal diseases. Unravelling the complexity of the retinal connexins' biology is essential to designing effective therapeutic strategies. For instance, new drugs or connexin mimetic peptides that selectively modulate connexin isoforms in each cell type are currently explored as therapeutic options for retinal diseases. To date, Cx43 mimetic peptides have been tested for the treatment of different retinal pathologies.

Indexed as

ConnexinsGap JunctionsRetinal DiseasesAnimalsHumansMolecular Targeted TherapyRetinaConnexinsConnexinsGap-junctionsRetinaRetinal degenerationTherapy

Identifiers

PMID39930242

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.