Evidence map›Paper›PMID 39930271›Full record

ArticleOncogene2025

circAFF2 promotes the development of AML by binding to PML mRNA.

Lei Yao, Xinyang Zhang, Xiaoqing Li, Jin Xu, Siqi Yang, Fengyue Li, Wenbo Chen, Yuxin Shan, Linli Ren, Chenjian Zhuo and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lei Yao *College of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xinyang Zhang *TaiKang Medical School, Wuhan University, Wuhan, China.
Xiaoqing Li *Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jin Xu *Medical Research Institute, Wuhan University, Wuhan, China.
Siqi YangTaiKang Medical School, Wuhan University, Wuhan, China.
Fengyue LiCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Wenbo ChenTaiKang Medical School, Wuhan University, Wuhan, China.
Yuxin ShanCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Linli RenCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Chenjian ZhuoCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Sisi LiangCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Lu ChenHospital of Huazhong Agricultural University, Wuhan, China.
Weinan YinCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Hudan LiuMedical Research Institute, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0003-1362-6048
Lingbo LiuUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mingqian FengCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Ke ChenTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. kechen@hust.edu.cn.ORCID http://orcid.org/0000-0002-6914-6257
Shuliang ChenTaiKang Medical School, Wuhan University, Wuhan, China. chen-shuliang@whu.edu.cn.
Chunjiang HeCollege of Biomedicine and Health, Hubei Hongshan Laboratory, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China. che@whu.edu.cn.ORCID http://orcid.org/0000-0002-4868-331X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AML is a complex disease caused by multiple molecular mechanisms. As an important regulatory molecule, the role of circRNA in AML is not fully understood. By performing high-throughput sequencing on clinical samples, we systematically identified the differences in circRNA expression and distribution between AML and healthy donor samples. One circular RNA, circAFF2, was found to be significantly upregulated in AML patients. Functional studies showed that knockdown of circAFF2 could significantly inhibit the proliferation of AML cells and promote their apoptosis. Overexpression of circAFF2 can have opposite effects. In vivo experiments showed that transplantation of AML cells with circAFF2 knockdown slowed the proliferation and infiltration and prolonged the survival time of mice compared to controls. Further studies showed that circAFF2 can promote the degradation of PML mRNA by binding to the 3'UTR of PML mRNA, thereby affecting the proliferation and apoptosis of AML cells. In conclusion, our work demonstrates that circAFF2 can bind to PML mRNA to regulate AML cell function, providing new insights into the mechanism of AML development and potential targets for clinical diagnosis and treatment.

Indexed as

Leukemia, Myeloid, AcutePromyelocytic Leukemia ProteinRNA, CircularRNA, Messenger3' Untranslated RegionsAnimalsApoptosisCell Line, TumorCell ProliferationFemaleGene Expression Regulation, LeukemicHumansMaleMice3' Untranslated RegionsPML protein, humanPromyelocytic Leukemia ProteinRNA, CircularRNA, Messenger

Identifiers

PMID39930271

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.