ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Role of EZH2-mediated abnormal histone H3K27me3 methylation in pressure overload-induced cardiac remodeling in mice.
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- miR-138-5p Promotes HF in Rats by Reducing Histone Methylation in the Myd88 Promoter Region through Inhibition of EZH2.Acta Cardiologica Sinica · 2026Article
- EZH2 promotes malignant biological behavior in esophageal squamous cell carcinoma via EMT.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCardiac remodeling is a critical pathological process leading to heart failure. Currently, there is a lack of specific and effective therapies targeting pathological cardiac remodeling. Epigenetics has been shown to play a regulatory role in pathological remodeling. This study aims to explore the impact of inhibiting histone methyltransferase enhancer of zeste homolog 2 (EZH2)-mediated abnormal histone 3 lysine 27 trimethylation (H3K27me3) methylation modification on the progression of pressure overload-induced cardiac remodeling in mice.
methodsMale Kunming mice (specific pathogen-free grade) were randomly divided into groups for 2 experimental parts. Thoracic aortic constriction (TAC) surgery was performed to establish a mouse model of pressure overload-induced cardiac remodeling. In part 1, mice were divided into Normal, Sham, TAC-4W (TAC 4 weeks post-surgery), and TAC-8W (TAC 8 weeks post-surgery) groups. In part 2, mice were divided into Normal, Sham, TAC-8W, TAC+Vehicle (Veh) (TAC with distilled water gavage), and TAC+tanshinone I (Tan I) (TAC with Tan I gavage) groups. Cardiac structure and function were assessed using echocardiography. Histological analysis, Western blotting, and wheat germ agglutinin (WGA) staining was used to evaluate myocardial tissue and cellular changes.
resultsGross examination revealed that the hearts of mice in the TAC-8W group were larger than those in the Sham group, and the hearts in the TAC+Tan I group were further enlarged compared to the TAC-8W group. Echocardiographic analysis showed that, compared to the Sham group, mice in the TAC-4W group exhibited significantly increased left ventricular anterior wall thickness (LVAWT), left ventricular posterior wall thickness (LVPWT), and left ventricular ejection fraction (LVEF), while left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) were significantly decreased (all
conclusionsEZH2 inhibition-mediated reduction in H3K27me3 methylation promotes pressure overload-induced cardiac remodeling in mice. EZH2 may serve as a novel therapeutic target for the prevention and treatment of pathological cardiac remodeling.
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