Evidence map›Paper›PMID 39931921›Full record

ArticleJournal of neuroscience research2025

Transcorneal Electrical Stimulation Modulates Visual Pathway Function in Mice.

Valerio Castoldi, Elena Rossi, Silvia Marenna, Giancarlo Comi, Letizia Leocani

Abstract read
In one paragraph

Article in Journal of neuroscience research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valerio CastoldiExperimental Neurophysiology Unit, Institute of Experimental Neurology (INSPE) - IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-8136-3422
Elena RossiExperimental Neurophysiology Unit, Institute of Experimental Neurology (INSPE) - IRCCS San Raffaele Scientific Institute, Milan, Italy.
Silvia MarennaExperimental Neurophysiology Unit, Institute of Experimental Neurology (INSPE) - IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giancarlo ComiFaculty of Medicine, Università Vita-Salute San Raffaele, Milan, Italy.
Letizia LeocaniExperimental Neurophysiology Unit, Institute of Experimental Neurology (INSPE) - IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-9326-6753

Funding

Italian Ministry of Education, University and Research through the IVASCOMAR project (CTN01_00177_165430, Cluster Tecnologico Nazionale Scienze della Vita "Alisei")Lombardy Region (POR FESR 2014-2020) within the framework of the NeOn project (ID 239047)
6 · The paper itself

Abstract

Due to its ability to modulate neuronal activity, electrical stimulation of the eye may be a promising therapy for preserving or restoring vision. To investigate how electrical currents can influence visual function, Transcorneal Electrical Stimulation (TES) was tested on both female and male C57BL/6 mice to evaluate its neuromodulatory effect from the retina to the cerebral cortex through visual evoked potential (VEP) and electroretinogram (ERG) recording. VEP or ERG was acquired before (baseline), immediately (t0), after 5 min (t5), and 10 min (t10) of sham (i.e., no stimulation) or TES applied on the eye of anesthetized C57BL/6 mice. Notably, TES affected neuronal activity in the visual pathway since a significant increase in VEP and ERG amplitude was detected and persisted 10 min after TES. The amplitude increase induced by TES could underlie an enhancement of neuronal excitability that may ameliorate retinal-genicular-cortical function in diseases involving the visual system.

Indexed as

CorneaElectric StimulationEvoked Potentials, VisualVisual PathwaysAnimalsElectroretinographyFemaleMaleMiceMice, Inbred C57BLPhotic StimulationRetinaelectroretinogramneuromodulationoptic nerveretinavisual evoked potential

Identifiers

PMID39931921
PMCPMC11811922

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.