Evidence map›Paper›PMID 39932450›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Gallbladder-Specific Hydrophobic Bile Acid-FXR-MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation.

Hongtan Chen, Xin Jiang, Yiqiao Li, Honggang Guo, Jianguo Wu, Sha Li, Fengling Hu, Guoqiang Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Gut fungi exacerbates gallstone formation by activating neutrophil extracellular traps in the liver.Apoptosis : an international journal on programmed cell death · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongtan ChenDivision of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China.
Xin JiangDivision of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China.ORCID https://orcid.org/0000-0002-1343-1323
Yiqiao LiDivision of Nephrology, Zhejiang Provincial People's Hospital, Hangzhou Medical College Affiliated Hospital, Hangzhou, Zhejiang, 310014, China.
Honggang GuoLaboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences, Medical College, Hangzhou, Zhejiang, 310063, China.
Jianguo WuClinical laboratory, Zhejiang Provincial People's Hospital, Hangzhou Medical College Affiliated Hospital, Hangzhou, Zhejiang, 310014, China.
Sha LiDivision of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China.
Fengling HuDivision of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China.
Guoqiang XuDivision of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310002, China.

Funding

National Natural Science Foundation of China 81870433National Natural Science Foundation of China 82170649National Natural Science Foundation of China 82300729National Natural Science Foundation of China 82400748Natural Science Foundation of Zhejiang province LGJ18H030001
6 · The paper itself

Abstract

Differences in the distribution of hydrophilic and hydrophobic bile acids (BA) are observed in mouse models of non-alcoholic fatty liver disease (NAFLD) induced by a high-fat-cholesterol "Western-style" diet (WD), and cholesterol gallstone disease (CGD) induced by a lithogenic diet. Despite sharing common pathological processes, these models exhibit distinct characteristics in their BA pools. The study investigates the impact of hydrophobic BA (

Indexed as

Bile Acids and SaltsCholesterolGallbladderGallstonesMucin-1Receptors, Cytoplasmic and NuclearAnimalsDisease Models, AnimalHumansHydrophobic and Hydrophilic InteractionsMaleMiceMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseaseReceptor, Farnesoid X-ActivatedBile Acids and SaltsCholesterolMucin-1Receptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearcaveolaecholesterol gallstonefarnesoid X receptorhydrophobic bile acid poolprotein kinase Cζ

Identifiers

PMID39932450
PMCPMC11967835

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.