Evidence map›Paper›PMID 39933529›Full record

ArticleCell reports. Medicine2025

Nanrilkefusp alfa (SOT101), an IL-15 receptor βγ superagonist, as a single agent or with anti-PD-1 in patients with advanced cancers.

Stephane Champiat, Elena Garralda, Vladimir Galvao, Philippe A Cassier, Carlos Gomez-Roca, Iphigenie Korakis, Peter Grell, Aung Naing, Patricia LoRusso, Romana Mikyskova and 13 more

Abstract readClinical Trial, Phase I
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Stephane ChampiatGustave Roussy, Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP), Universite Paris Saclay, 94805 Villejuif, France. Electronic address: schampiat@mdanderson.org.
Elena GarraldaVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
Vladimir GalvaoVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
Philippe A CassierDepartment of Medical Oncology, Centre Leon Berard, 69008 Lyon, France.
Carlos Gomez-RocaInstitut Universitaire du Cancer de Toulouse, 31100 Toulouse, France.
Iphigenie KorakisInstitut Universitaire du Cancer de Toulouse, 31100 Toulouse, France.
Peter GrellMasaryk Memorial Cancer Institute, 602 00 Brno, Czech Republic.
Aung NaingDepartment of Lnvestigational Cancer Therapeutics, MD Anderson Cancer Center, Houston, TX 77030, USA.
Patricia LoRussoYale School of Medicine, New Haven, CT 06510, USA.
Romana MikyskovaLaboratory of Immunological and Tumor Models, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Nada PodzimkovaSOTIO Biotech a.s., 170 00 Prague, Czech Republic.
Milan ReinisLaboratory of Immunological and Tumor Models, Institute of Molecular Genetics of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Kaissa OualiGustave Roussy, Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP), Universite Paris Saclay, 94805 Villejuif, France.
Andreu SchoenenbergerSOTIO Biotech a.s., 170 00 Prague, Czech Republic.
Joachim Kiemle-KalleeSOTIO Biotech AG, 4056 Basel, Switzerland.
Sascha TillmannsSOTIO Biotech AG, 4056 Basel, Switzerland.
Richard SachseSOTIO Biotech AG, 4056 Basel, Switzerland.
Ulrich MoebiusSOTIO Biotech a.s., 170 00 Prague, Czech Republic.
Radek SpisekSOTIO Biotech a.s., 170 00 Prague, Czech Republic.
David BechardCytune Pharma, 44300 Nantes, France.
Lenka Palova JelinkovaSOTIO Biotech a.s., 170 00 Prague, Czech Republic; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, 150 06 Prague, Czech Republic.
Irena AdkinsSOTIO Biotech a.s., 170 00 Prague, Czech Republic; Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, 150 06 Prague, Czech Republic.
Aurelien MarabelleGustave Roussy, Departement d'Innovation Therapeutique et d'Essais Precoces (DITEP), Universite Paris Saclay, 94805 Villejuif, France.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Nanrilkefusp alfa (nanril; SOT101) is an interleukin (IL)-15 receptor βγ superagonist that stimulates natural killer (NK) and CD8

Indexed as

NeoplasmsProgrammed Cell Death 1 ReceptorReceptors, Interleukin-15AdultAgedAnimalsAntibodies, Monoclonal, HumanizedCD8-Positive T-LymphocytesFemaleHumansImmune Checkpoint InhibitorsKiller Cells, NaturalMacaca fascicularisMaleMiddle AgedAntibodies, Monoclonal, HumanizedImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorReceptors, Interleukin-15anti-tumor efficacynanrilnanrilkefusp alfapembrolizumab combinationsolid tumorsSOT101

Identifiers

PMID39933529
PMCPMC11866505

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.