Evidence map›Paper›PMID 39933556›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2025

Perceived Stress is Associated with Health Outcomes, Platelet Activation, and Oxidative Stress in COPD.

Obiageli Offor, Michelle N Eakin, Han Woo, Daniel Belz, Marlene Williams, Sarath Raju, Meredith McCormack, Nadia N Hansel, Nirupama Putcha, Ashraf Fawzy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Obiageli OfforDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Michelle N EakinDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Han WooDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Daniel BelzDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Marlene WilliamsDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, United States.
Sarath RajuDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Meredith McCormackDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Nadia N HanselDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Nirupama PutchaDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.
Ashraf FawzyDivision of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland, United States.

Funding

MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
The Environmental Assessments Core (FSC)P50MD010431 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, KIRSTEN ANNE · 2015 to 2019
$3.5M
Platelet Activation Pathways and Respiratory Morbidity in COPDK23HL151758 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FAWZY, ASHRAF · 2021 to 2025
$986k
The role of platelet activation and particulate matter exposure in COPD morbidityF32ES028576 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI FAWZY, ASHRAF · 2017 to 2018
$135k
EPA 83615001National Institute for Minority Health and Health Disparities P50MD010431NHLBI NIH HHS K23 HL151758NHLBI NIH HHS K23HL151758NHLBI NIH HHS T32 HL007534NHLBI NIH HHS T32HL007534NIEHS NIH HHS F32 ES028576NIEHS NIH HHS F32ES028576NIMHD NIH HHS P50 MD010431
6 · The paper itself

Abstract

Background: Individuals with chronic obstructive pulmonary disease (COPD) are disproportionately affected by social determinants of health that have been associated with worse respiratory outcomes. This study evaluates the association of perceived stress with respiratory outcomes and distinct biological mechanisms among former smokers with COPD. Methods: Participants were assessed in an observational study at baseline, 3-months, and 6-months. Questionnaires assessed perceived stress (Perceived Stress Scale, [PSS]), respiratory symptoms, and incidence of COPD exacerbations. Generalized linear mixed models evaluated the association of PSS score with COPD outcomes and biomarkers of platelet activation (urine 11-dehydro-thromboxane B2 [11dTxB2]), oxidative stress (urine thiobarbituric acid reactive substances [TBARS], 8- hydroxydeoxyguanosine, and 8-isoprostane), and inflammation. Results: Among 99 participants, the median PSS score was 13 (interquartile range 8-18) across all visits. Compared with low perceived stress (PSS 0-13), moderate (PSS 14-26) and high perceived stress (PSS 27-40) were associated with worse respiratory health status and respiratory-related quality of life, with point estimates for high perceived stress exceeding clinically important differences. Only high PSS was associated with increased moderate/severe exacerbations (odds ratio 4.15, 95% confidence interval [CI]: 1.28-13.47). Compared to low stress, high stress was associated with lower TBARS (β=-25.5%, 95%CI: -43.8- -1.2%) and higher 8-isoprostane (β=40.1%, 95%CI: 11.5-76.0%). Among individuals with mild-moderate COPD, compared to low stress, moderate (β=20.1%, 95%CI: 3.1-40.0%) and high (β=52.9%, 95%CI: 22.1-91.6%) stress were associated with higher 11dTxB2. Conclusion: Among former smokers with COPD, higher perceived stress is associated with worse respiratory outcomes. Platelet activation and oxidative stress may be biological pathways through which perceived stress plays a role in COPD.

Indexed as

COPDoutcomesoxidative stressperceived stressplatelet activation

Identifiers

PMID39933556
PMCPMC12147820

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.