ArticleSaudi medical journal2025
GLP-1RA and SGLT2i utilization in people with type 2 diabetes with atherosclerotic cardiovascular disease (ASCVD) or at high risk of ASCVD in the Gulf Region: Results from the PACT-MEA studys.
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Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Modern Management of CKM Syndrome: Use of GLP-1 Receptor Agonists in a Multidisciplinary Setting-Expert Group Recommendations from Kuwait.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Use of Fixed Ratio Combinations to Improve Glycemic Control in Individuals with Type 2 Diabetes: Experts' Opinion from the Gulf Region.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Comment on: GLP-1RA and SGLT2i utilization in people with type 2 diabetes with atherosclerotic cardiovascular disease (ASCVD) or at high risk of ASCVD in the Gulf Region.Saudi medical journal · 2025Article
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Authors and funding
13 authors.
Waleed A Al-DahiFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Saeed H KhalafFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Dalal A AlRomaihiFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Naji M AlamuddinFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Hessa M Al KandariFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Doaa K AbdallaFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Hanan Y AlfadehlaFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Amin A JayyousiFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Mashhood A SiddiqueFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Usama A AlAlamiFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Guruprasad C SubbaraoFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Shashikanth J ChettyFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.
Jehan A AbdullaFrom the Department of Internal Medicine (Al-Dahi), Mubarak Hospital, Al Jairiyah; from the Department of Pediatric Endocrinology (Al Kandari), Farwaniya Hospital; from the Department of Endocrinology (Al Kandari, Abdalla), Dasman Diabetes Institute, Dasma; from the Department of Primary Care (Abdalla, Alfadehla) Yarmouk Primary Health Care Centre, Al Yarmūk; from the Department of Medical Affairs (AlAlami, Subbarao, Chetty), Novo Nordisk Gulf Cluster, Salmiya, Kuwait; from the Department of Endocrinology (Khalaf), Salmaniya Medical Complex, Manama; from the Department of Endocrinology (AlRomaihi), Awali Hospital, Awali; Department of Internal Medicine (Alamuddin), King Hamad University Hospital, Adliya; from the Department of Endocrinology (Abdulla), Bahrain Defence Force Hospital, West Riffa, Bahrain; and from the Department of Endocrinology (Jayyousi, Siddique), Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0003-0393-9139
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo provide insights into the real-world usage of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) among individuals with type 2 diabetes (T2D) from Bahrain, Kuwait, and Qatar who either had established atherosclerotic cardiovascular disease (eASCVD) or were at high risk of developing ASCVD.
methodsThis study of 1062 adults diagnosed with T2D from Bahrain, Kuwait, and Qatar is a sub-analysis within the Prevalence and Clinical Management of Atherosclerotic Cardiovascular Diseases in Patients with Type 2 Diabetes across Countries in the Middle East and Africa (PACT-MEA) study, a noninterventional, cross-sectional study. Participants were recruited from 13 primary or secondary care facilities between March and August 2022. Medical records of participants were reviewed to extract relevant data, including demographic characteristics, eASCVD status, ASCVD risk and glucose-lowering treatment. Appropriate descriptive and inferential statistical tests were performed.
resultsAmong T2D participants with eASCVD, a significantly higher proportion (41.3%) received SGLT2i compared to GLP-1RA (10.5%,
conclusionDespite these cardioprotective agents being recommended by guidelines, the study findings suggest a suboptimal use of GLP-1RA and SGLT2i in a real-world setting.
Indexed as
AtherosclerosisDiabetes Mellitus, Type 2Glucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsSodium-Glucose Transporter 2 InhibitorsAdultAgedBahrainCross-Sectional StudiesFemaleHumansKuwaitMaleMiddle AgedMiddle EastQatarGlucagon-Like Peptide-1 Receptor AgonistsHypoglycemic AgentsSodium-Glucose Transporter 2 Inhibitorsatherosclerosiscardiovascular diseasesDiabetes mellitushypoglycemic agentsMiddle Easttype 2
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