Evidence map›Paper›PMID 39933792›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2025

Retinoic acid signaling and metabolism in heart failure.

Lauren E Parker, Kyriakos N Papanicolaou, Stephanie Zalesak-Kravec, Eva M Weinberger, Maureen A Kane, D Brian Foster

Abstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Vitamin A deficiency attenuates cardiac rupture inFrontiers in cardiovascular medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lauren E ParkerDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.
Kyriakos N PapanicolaouDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.
Stephanie Zalesak-KravecSchool of Pharmacy, University of Maryland, Baltimore, Maryland, United States.
Eva M WeinbergerSchool of Medicine, Imperial College London, London, United Kingdom.
Maureen A KaneSchool of Pharmacy, University of Maryland, Baltimore, Maryland, United States.
D Brian FosterDivision of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-9290-9590

Funding

TASK ORDER B-1, ANIMAL MODEL DEVELOPMENT AND EFFICACY TESTING OF CANDIDATE MCMS75N93020D00011 · NIAID · SRI INTERNATIONAL · 2020 to 2025
$86.2M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Retinoid Metabolism in the Adult Heart and Heart FailureR01HL164478 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI D Brian Foster, MAUREEN A KANE · 2023 to 2026
$2.8M
Targeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1M
Preclinical Services for Biopharmaceutical Product Development75N93023D00011 · NIAID · ALLUCENT GOVERNMENT SERVICES (US) LLC · 2023 to 2023
$7k
American Heart Association (AHA) CDA935823American Heart Association (AHA) TPA34170575CLC NIH HHS 75N90020D00011HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL134821HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL164478Johns Hopkins University (JHU) Woodrow Wilson FellowshipNHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL164478NIAID NIH HHS 75N93020D00011NIAID NIH HHS 75N93023D00011NIAID NIH HHS HHSN272201000046CNIAID NIH HHS HHSN272201500013INIGMS NIH HHS T32 GM145449ORFDO NIH HHS 75N99020D00011Saving Tiny Hearts Society (StHS) PD00180632University of Maryland School of Pharmacy PD 00180632
6 · The paper itself

Abstract

Nearly 70 years after studies first showed that the offspring of vitamin A (retinol, ROL)-deficient rats exhibit structural cardiac defects and over 20 years since the role of vitamin A's potent bioactive metabolite hormone, all

Indexed as

Heart FailureMyocardiumSignal TransductionTretinoinAnimalsHumansTretinoinheart diseaseheart failuremetabolismretinoic acidvitamin A

Identifiers

PMID39933792
PMCPMC12306655

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.