In one paragraphArticle in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Hanne Lie KjærstadNeurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-7781-8853 Florien RitsmaNeurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Klara CoelloCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Mental Health Services, Frederiksberg, Capital Region of Denmark.ORCID 0000-0003-1568-2991 Sharleny StanislausCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Mental Health Services, Frederiksberg, Capital Region of Denmark.ORCID 0000-0003-1073-6436 Klaus MunkholmCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Mental Health Services, Frederiksberg, Capital Region of Denmark.ORCID 0000-0001-6437-0359 Maria Faurholt-JepsenCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Mental Health Services, Frederiksberg, Capital Region of Denmark.ORCID 0000-0002-0462-6444 Julian MacoveanuNeurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-6148-9477 Anne Juul BjertrupNeurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2726-9777 Maj VinbergDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5982-1335 Lars Vedel KessingCopenhagen Affective Disorder research Centre (CADIC), Psychiatric Centre Copenhagen, Frederiksberg Hospital, Mental Health Services, Frederiksberg, Capital Region of Denmark.ORCID 0000-0001-9377-9436 Kamilla Woznica MiskowiakNeurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2572-1384 Funding
Augustinus Fonden 16-0083Copenhagen Center for Health Technology EU project 722561Gangstedfonden A29594Helsefonden 16-B-0063Innovationsfonden 5164-00001BMarkedsmodningsfonden 2015-310Sundhed og Sygdom, Det Frie Forskningsråd DFF-4183-00570
6 · The paper itselfAbstract
backgroundImpaired emotion regulation has been proposed as a putative endophenotype in bipolar disorder (BD). Functional magnetic resonance imaging (fMRI) studies investigating this in unaffected first-degree relatives (UR) have thus far yielded incongruent findings. Hence, the current paper examines neural subgroups among UR during emotion regulation.
methods71 UR of patients with BD and 66 healthy controls (HC) underwent fMRI scanning while performing an emotion regulation task. Hierarchical cluster analysis was performed on extracted signal change during emotion down-regulation in pre-defined regions of interest (ROIs). Identified subgroups were compared on neural activation, demographic, clinical, and cognitive variables.
resultsTwo subgroups of UR were identified: subgroup 1 (39 UR; 55%) was characterized by
conclusionsThese findings may explain the discrepancy in earlier fMRI studies on emotion regulation in UR, showing two different subgroups of UR that both exhibited aberrant neural activity during emotion regulation, but in opposite directions. Furthermore, the results suggest that impaired recognition of positive facial expressions is a broad endophenotype of BD.
Indexed as
AmygdalaBipolar DisorderEmotional RegulationFamilyPrefrontal CortexAdultEndophenotypesFacial RecognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adultbipolar disordercluster analysisemotion regulationendophenotypesfMRIrelatives
Identifiers
PMID39934008
PMCPMC12055023
What Socratic holds
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