Evidence map›Paper›PMID 39935376›Full record

ArticleBiomarkers in medicine2025

Left ventricular remodeling in atrial fibrillation is associated with elevated NAP-2 and 3-nitrotyrosine.

Patrycja Mołek-Dziadosz, Joanna Natorska, Paweł T Matusik, Wiktoria Wojciechowska, Marek Rajzer, Renata Rajtar-Salwa, Stanisław Bartuś, Andrzej Surdacki, Krzysztof P Malinowski, Aleksandra Lenart-Migdalska and 2 more

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Patrycja Mołek-DziadoszDepartment of Coronary Artery Disease and Heart Failure, Jagiellonian University Medical College, Krakow, Poland.
Joanna NatorskaKrakow Centre for Medical Research and Technologies, The St. John Paul II Hospital, Krakow, Poland.
Paweł T MatusikInstitute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
Wiktoria Wojciechowska1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Kraków, Poland.
Marek Rajzer1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Kraków, Poland.
Renata Rajtar-SalwaDepartment of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland.
Stanisław BartuśDepartment of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland.
Andrzej SurdackiDepartment of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland.
Krzysztof P MalinowskiDepartment of Bioinformatics and Telemedicine, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
Aleksandra Lenart-MigdalskaDepartment of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
Maria OlszowskaDepartment of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland.
Michał ZąbczykKrakow Centre for Medical Research and Technologies, The St. John Paul II Hospital, Krakow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) coexists with left ventricular (LV) dysfunction and remodeling. Neutrophil infiltration of cardiac muscle tissue and oxidative stress are associated with cardiac remodeling. MATERIALS AND

methodsIn 221 AF patients aged 70 (62-76) years, LV remodeling was assessed using echocardiography. Plasma concentrations of neutrophil-activating peptide 2 (NAP-2) and 3-nitrotyrosine were measured.

resultsAF patients with concentric and eccentric hypertrophy showed higher NAP-2 levels than those with normal LV geometry (+41% and + 29%,

conclusionsElevated NAP-2, associated with oxidative damage, may contribute to the development of LV hypertrophy.

Indexed as

Atrial FibrillationTyrosineVentricular RemodelingAgedBiomarkersEchocardiographyFemaleHumansMaleMiddle Aged3-nitrotyrosineBiomarkersTyrosineAtrial fibrillationcardiac hypertrophycardiac remodelinginflammationoxidative stress

Identifiers

PMID39935376
PMCPMC11916376

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.