Evidence map›Paper›PMID 39935869›Full record

ArticleAPL bioengineering2025

Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations.

Wen Yih Aw, Aanya Sawhney, Mitesh Rathod, Chloe P Whitworth, Elizabeth L Doherty, Ethan Madden, Jingming Lu, Kaden Westphal, Ryan Stack, William J Polacheck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Wen Yih AwJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0002-1724-412X
Aanya SawhneyJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0009-0002-3827-9580
Mitesh RathodJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0003-1315-612X
Chloe P WhitworthORCID https://orcid.org/0000-0001-5726-6158
Elizabeth L DohertyJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0002-4793-2695
Ethan MaddenDepartment of Genetics and Molecular Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA.ORCID https://orcid.org/0009-0005-7985-1426
Jingming LuJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0000-0002-5791-4861
Kaden WestphalJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0009-0001-6013-3724
Ryan StackJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, North Carolina 27514, USA.ORCID https://orcid.org/0009-0005-0684-8226
William J PolacheckORCID https://orcid.org/0000-0003-2728-0746

Funding

Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
NRSA in GeneticsT32GM135128 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay, JEFF J. SEKELSKY · 2020 to 2026
$5.1M
Integrative Approaches for the Study of the Fluidic Cellular MicroenvironmentR35GM142944 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William J Polacheck · 2021 to 2026
$2.3M
Defining the role of extracellular matrix mechanics in vascular Ehlers-Danlos syndromeF31HL162462 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOHERTY, ELIZABETH LOUISE · 2022 to 2023
$73k
NHLBI NIH HHS F31 HL162462NHLBI NIH HHS T32 HL069768NIGMS NIH HHS R35 GM142944NIGMS NIH HHS T32 GM135128
6 · The paper itself

Abstract

Somatic activating mutations in

Identifiers

PMID39935869
PMCPMC11811908

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.