Evidence map›Paper›PMID 39936320›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

East and South Asian-Specific Blood Pressure Trajectories and Cardiovascular Disease.

So Mi J Cho, Sarah Urbut, Yunfeng Ruan, Aarushi Bhatnagar, Shriienidhie Ganesh, Whitney E Hornsby, Romit Bhattacharya, Michael C Honigberg, Stephen P Juraschek, Eugene Yang and 2 more

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Aldosterone-renin ratio and plasma renin activity as biomarkers for treatment response in resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Obesity, Hypertension and Brain Health.Current hypertension reports · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

So Mi J ChoProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0003-2460-3335
Sarah UrbutProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0002-1135-9647
Yunfeng RuanProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0002-3213-8309
Aarushi BhatnagarCardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M.J.C., S.U., Y.R., A.B., S.G., W.E.H., R.B., M.C.H., P.N.).
Shriienidhie GaneshCardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (S.M.J.C., S.U., Y.R., A.B., S.G., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0002-4226-7526
Whitney E HornsbyProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0002-0672-0338
Romit BhattacharyaProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0002-0782-4753
Michael C HonigbergProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).
Stephen P JuraschekDepartment of Medicine, Harvard Medical School, Boston, MA (R.B., M.C.H., S.P.J., P.N.).ORCID 0000-0003-4168-2696
Eugene YangDivision of Cardiology, University of Washington School of Medicine, Seattle (E.Y.).ORCID 0000-0003-3945-7529
Daichi ShimboColumbia Hypertension Lab, Department of Medicine, Columbia University Irving Medical Center, New York, NY (D.S.).ORCID 0000-0001-6302-8834
Pradeep NatarajanProgram in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., S.U., Y.R., W.E.H., R.B., M.C.H., P.N.).ORCID 0000-0001-8402-7435

Funding

Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3M
Clonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9M
Clonal hematopoiesis in humans: determinants of development and progressionR01HL148050 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BALLANTYNE, CHRISTIE MITCHELL, NATARAJAN, PRADEEP · 2019 to 2022
$5.9M
Enabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5M
Whole genome sequences in individuals to comprehensively characterize the genetic mechanisms of dyslipidemiasR01HL142711 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama, Gina Marie Peloso · 2019 to 2026
$4.7M
CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL IN CHRONIC KIDNEY DISEASE PATIENTSR01DK125782 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KELLY, TANIKA NICOLE · 2021 to 2025
$3.3M
Stress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)R01HL135242 · NHLBI · UNIVERSITY OF UTAH · PI NATARAJAN, PRADEEP · 2017 to 2020
$2.8M
Clonal hematopoiesis of indeterminate potential and HIV in the REPRIEVE trialR01HL151283 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NATARAJAN, PRADEEP · 2020 to 2023
$2.5M
Clonal hematopoiesis as a mediator of cardiovascular disease in women with premature menopauseK08HL166687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HONIGBERG, MICHAEL · 2023 to 2025
$507k
NHGRI NIH HHS U01 HG011719NHLBI NIH HHS K08 HL166687NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL151283NIDDK NIH HHS R01 DK125782
6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) risk differs across Asian subgroups, possibly due to differences in hypertension burden. We characterized lifetime blood pressure (BP) trajectories for East and South Asian individuals and compared their associations with CVD risk.

methodsAmong 148 872 UK Biobank participants with primary care utilization data, life course BP trajectories were fitted as a function of age by sex according to self-identified ethnicity. We determined associations of time-averaged young adulthood (18-39 years), middle age (40-64 years), and later life (≥65 years) systolic BP (SBP) and diastolic BP with incident atherosclerotic CVD risk.

resultsThe predicted SBP/diastolic BP (95% CI) at age 30 years was 108 (103-114)/68 (65-71) mm Hg for East Asian and 114 (110-118)/72 (71-73) mm Hg for South Asian individuals. By age 40, South Asian individuals were projected to reach an SBP of 130.0 mm Hg, whereas East Asian individuals reached the equivalent SBP by age 49 years. Among South Asian individuals, each SD increase in young adulthood SBP was associated with a higher atherosclerotic CVD risk with an odds ratio (95% CI) of 1.41 (1.12-1.75), but not among East Asians (

conclusionsEast and South Asian individuals exhibit distinct BP trajectories that age-differentially associate with incident CVD. Disaggregating Asian subgroups may inform tailored hypertension screening and management.

Indexed as

Asian PeopleBlood PressureCardiovascular DiseasesHypertensionAdolescentAdultAgedFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsUnited KingdomYoung Adultasianblood pressurecardiovascular diseasesepidemiologyhypertension

Identifiers

PMID39936320
PMCPMC11839333

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.