Evidence mapPaperPMID 39936635Full record

ArticleeLife2025

Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca

Erli Jin, Jennifer K Briggs, Richard K P Benninger, Matthew J Merrins

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Erli Jin *Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0009-0002-9410-9738
Jennifer K Briggs *Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID https://orcid.org/0000-0002-8737-2215
Richard K P BenningerDepartment of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID https://orcid.org/0000-0002-5063-6096
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0003-1599-9227

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$1.3M
Mechanisms of islet compensation for β-cell mass deficiency in diabetesR01DK139640 · YALE UNIVERSITY · 2025 to 2025
$719k
Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · YALE UNIVERSITY · 2025 to 2025
$685k
Developing ultrasound contrast agents and signal processing for structural and functional imaging in type 1 diabetesR01DK140904 · UNIVERSITY OF COLORADO DENVER · 2025 to 2025
$643k
Metabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta-cellsR01DK113103 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$485k
Biomedical Laboratory Research and Development, VA Office of Research and Development I01BX005113BLRD VA I01 BX005113National Science Foundation DGE-1938058_BriggsNIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK102950NIDDK NIH HHS R01DK102950NIDDK NIH HHS R01 DK106412NIDDK NIH HHS R01DK106412NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01DK113103NIDDK NIH HHS R01 DK127637NIDDK NIH HHS R01DK127637NIDDK NIH HHS R01 DK139640NIDDK NIH HHS R01 DK140904NIDDK NIH HHS R01DK140904
6 · The paper itself

Abstract

Oscillations in insulin secretion, driven by islet Ca

Indexed as

CalciumCalcium SignalingGlucokinaseInsulin-Secreting CellsAnimalsImaging, Three-DimensionalMiceCalciumGlucokinasecalcium oscillationcell biologyglucokinaselight-sheet microscopemousepancreatic isletsβ-cell

Identifiers

PMID39936635
PMCPMC11820133

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.