A larval zebrafish model of traumatic brain injury: optimizing the dose of neurotrauma for discovery of treatments and aetiology.

Laszlo F Locskai, Taylor Gill, Samantha A W Tan, Alexander H Burton, Hadeel Alyenbaawi, Edward A Burton, W Ted Allison

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Article in Biology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Laszlo F LocskaiDepartment of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada.

Taylor GillDepartment of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada.

Samantha A W TanDepartment of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada.

Alexander H BurtonDepartments of Chemical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Hadeel AlyenbaawiDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia.

Edward A BurtonDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-8072-4636

W Ted AllisonDepartment of Biological Sciences, University of Alberta, Edmonton AB, T6G 2E9, Canada.ORCID 0000-0002-8461-4864

Funding

Alzheimer Society of Alberta and Northwest TerritoriesBLRD VA I01 BX003168Canadian Institutes of Health Research (CIHR)Majmaah UniversityNatural Sciences and Engineering Research Council of Canada (NSERC)University of AlbertaUS Department of Veterans Affairs I01-BX003168

6 · The paper itself

Abstract

Traumatic brain injuries (TBI) are diverse with heterogeneous injury pathologies, which creates challenges for the clinical treatment and prevention of secondary pathologies such as post-traumatic epilepsy and subsequent dementias. To develop pharmacological strategies that treat TBI and prevent complications, animal models must capture the spectrum of TBI severity to better understand pathophysiological events that occur during and after injury. To address such issues, we improved upon our recent larval zebrafish TBI paradigm emphasizing titrating to different injury levels. We observed coordination between an increase in injury level and clinically relevant injury phenotypes including post-traumatic seizures (PTS) and tau aggregation. This preclinical TBI model is simple to implement, allows dosing of injury levels to model diverse pathologies, and can be scaled to medium- or high-throughput screening.

Indexed as

Brain Injuries, TraumaticDisease Models, AnimalZebrafishAnimalsLarvaEpilepsyNeurodegenerationNeurotraumaPost-traumatic seizuresTauopathyTraumatic brain injury

Identifiers

PMID39936823

DOI10.1242/bio.060601

PMCPMC11849975

What Socratic holds

Textmetadata

LicenceCC BY

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