Subcellular Compartmentalization of Glucose Mediated Insulin Secretion.

Zhongying Wang, Tatyana Gurlo, Leslie S Satin, Scott E Fraser, Peter C Butler

Abstract read

In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies.Cells · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhongying WangTranslational Imaging Center, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.

Tatyana GurloLarry L. Hillblom Islet Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90089, USA.

Leslie S SatinBrehm Diabetes Center, Caswell Diabetes Institute, Department of Pharmacology, University of Michigan, Ann Arbor, MI 38105, USA.

Scott E FraserTranslational Imaging Center, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, USA.

Peter C ButlerLarry L. Hillblom Islet Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90089, USA.

Funding

METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023

$9.1M

Larry Hillblom Foundation 2014-D-001-NET, 2021-D-007-FELNIDDK NIH HHS R01 DK046409NIH HHS R01DK46409

6 · The paper itself

Abstract

Regulation of blood glucose levels depends on the property of beta cells to couple glucose sensing with insulin secretion. This is accomplished by the concentration-dependent flux of glucose through glycolysis and oxidative phosphorylation, generating ATP. The resulting rise in cytosolic ATP/ADP inhibits K

Indexed as

GlucoseInsulinInsulin-Secreting CellsInsulin SecretionAdenosine TriphosphateAnimalsCalciumHumansMiceMitochondriaAdenosine TriphosphateCalciumGlucoseInsulinATPbeta cellscalciumcompartmentalizationinsulinKATP channelmitochondriaoxidative phosphorylationpulsatile secretionsubmembrane

Identifiers

PMID39936989

DOI10.3390/cells14030198

PMCPMC11817236

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.