Evidence map›Paper›PMID 39936997›Full record

ArticleCells2025

Early Synapse-Specific Alterations of Photoreceptor Mitochondria in the EAE Mouse Model of Multiple Sclerosis.

Dalia R Ibrahim, Karin Schwarz, Shweta Suiwal, Sofia Maragkou, Frank Schmitz

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dalia R IbrahimInstitute of Anatomy, Department of Neuroanatomy, Medical School Homburg, Saarland University, 66421 Homburg, Germany.ORCID 0009-0002-2554-1244
Karin SchwarzInstitute of Anatomy, Department of Neuroanatomy, Medical School Homburg, Saarland University, 66421 Homburg, Germany.ORCID 0000-0002-7328-1427
Shweta SuiwalInstitute of Anatomy, Department of Neuroanatomy, Medical School Homburg, Saarland University, 66421 Homburg, Germany.
Sofia MaragkouInstitute of Anatomy, Department of Neuroanatomy, Medical School Homburg, Saarland University, 66421 Homburg, Germany.
Frank SchmitzInstitute of Anatomy, Department of Neuroanatomy, Medical School Homburg, Saarland University, 66421 Homburg, Germany.ORCID 0000-0003-1457-6222

Funding

Dr. Rolf M. Schwiete Foundation 2021-022
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) linked to many neurological disabilities. The visual system is frequently impaired in MS. In previous studies, we observed early malfunctions of rod photoreceptor ribbon synapses in the EAE mouse model of MS that included alterations in synaptic vesicle cycling and disturbances of presynaptic Ca

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMitochondriaMultiple SclerosisRetinal Rod Photoreceptor CellsSynapsesAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMitochondrial ProteinsPresynaptic TerminalsMitochondrial ProteinsDRP1experimental autoimmune encephalomyelitis (EAE)extra-synaptic mitochondriaMIC60mitochondriamultiple sclerosisretinaribbon synapsesynaptic mitochondria

Identifiers

PMID39936997
PMCPMC11816939

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.