Evidence map›Paper›PMID 39938860›Full record

ArticleNeuropharmacology2025

Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats.

Alexandra Rogers, Emily M Castro, Shahrdad Lotfipour, Frances M Leslie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra RogersDepartment of Pharmaceutical Sciences, University of California, Irvine, 856 Health Sciences Road, Suite 5400, 92697-3958, Irvine, CA, USA. Electronic address: arogers2@uci.edu.
Emily M CastroDepartment of Pharmaceutical Sciences, University of California, Irvine, 856 Health Sciences Road, Suite 5400, 92697-3958, Irvine, CA, USA.
Shahrdad LotfipourDepartment of Pharmaceutical Sciences, University of California, Irvine, 856 Health Sciences Road, Suite 5400, 92697-3958, Irvine, CA, USA.
Frances M LeslieDepartment of Pharmaceutical Sciences, University of California, Irvine, 856 Health Sciences Road, Suite 5400, 92697-3958, Irvine, CA, USA.

Funding

Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
Comparative neurobehavioral pharmacology of combusted and non-combusted tobacco productsR01DA048899 · NIDA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI HARRIS, ANDREW CHARLES, LESAGE, MARK G · 2020 to 2024
$3.4M
Training Program in Substance Use and Use DisordersT32DA050558 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2020 to 2024
$892k
NIDA NIH HHS R01 DA048899NIDA NIH HHS T32 DA050558NINDS NIH HHS T32 NS045540
6 · The paper itself

Abstract

The highly plastic nature of the adolescent brain is well-known, and is thought to contribute to the unique susceptibility of adolescents to drugs of abuse. However, much investigation of adolescent plasticity has been focused on synaptic plasticity, as synapses are strengthened and pruned. Here, we show that dynorphin

Indexed as

DynorphinsHypothalamic Area, LateralVentral Tegmental AreaAnimalsEthanolMaleNeural PathwaysNeuronsNicotineRatsRats, Sprague-DawleyDynorphinsEthanolNicotineAddictionAdolescenceEthanolNicotineSusceptibilityVTA

Identifiers

PMID39938860
PMCPMC12434623

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.