Evidence map›Paper›PMID 39939140›Full record

ArticleJournal for immunotherapy of cancer2025

CD56

Maria L Guevara Lopez, Ann Gebo, Monica Parodi, Stefano Persano, Josephine Maus-Conn, Maria Cristina Mingari, Fabrizio Loiacono, Paola Orecchia, Simona Sivori, Claudia Cantoni and 9 more

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maria L Guevara LopezDepartment of Experimental Medicine (DIMES), University of Genoa, Genova, Italy giulia.bertolini@istitutotumori.mi.it maguevara.lop@gmail.com massimo.vitale@hsanmartino.it.ORCID http://orcid.org/0009-0008-1629-5639
Ann GeboDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Monica ParodiIRCCS Ospedale Policlinico San Martino, Genova, Italy.
Stefano PersanoDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Josephine Maus-ConnDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Maria Cristina MingariDepartment of Experimental Medicine (DIMES), University of Genoa, Genova, Italy.
Fabrizio LoiaconoIRCCS Ospedale Policlinico San Martino, Genova, Italy.
Paola OrecchiaIRCCS Ospedale Policlinico San Martino, Genova, Italy.
Simona SivoriDepartment of Experimental Medicine (DIMES), University of Genoa, Genova, Italy.ORCID http://orcid.org/0000-0003-1279-1172
Claudia CantoniDepartment of Experimental Medicine (DIMES), University of Genoa, Genova, Italy.
Marco GentiliFondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Federica FacchinettiFondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Riccardo FerraciniOspedale Koelliker, Turin, Italy.
Daniel A ValleraDepartment of Radiation Oncology, University of Minnesota, Minneapolis, Minnesota, USA.
Martin FelicesHematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0002-5945-0634
Giulia BertoliniFondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy giulia.bertolini@istitutotumori.mi.it maguevara.lop@gmail.com massimo.vitale@hsanmartino.it.ORCID http://orcid.org/0000-0002-8495-4594
Marco PravetoniDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Luca Roz *Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID http://orcid.org/0000-0001-5817-7149
Massimo Vitale *IRCCS Ospedale Policlinico San Martino, Genova, Italy giulia.bertolini@istitutotumori.mi.it maguevara.lop@gmail.com massimo.vitale@hsanmartino.it.ORCID http://orcid.org/0000-0001-5372-7885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to their enhanced responsiveness and persistence, cytokine-induced memory-like (CIML)-natural killer (NK) cells have emerged as new immunotherapeutic tools against malignancies. However, their effects on tumor-cell spread and metastases in solid tumors remain poorly investigated. Moreover, a clear identification of the most effective CIML-NK subsets, especially in controlling cancer stem cells (CSC), is still lacking.

methodsWe performed combined phenotypical and functional analyses of CIML-NK cell subsets, either selected by flow-cytometry gating, or generated from sorted CD56

resultsWe show that CIML-NK cells exert antitumor activity mostly through their CD56

conclusionsOur study discloses for the first time the therapeutic potential of CIML-NK cells in controlling CSCs and metastatic spread, highlighting the role of the CD56

Indexed as

Carcinoma, Non-Small-Cell LungCD56 AntigenKiller Cells, NaturalLung NeoplasmsNeoplastic Stem CellsAnimalsCell Line, TumorFemaleHumansImmunologic MemoryMiceCD56 AntigenNCAM1 protein, humanCytokineImmunotherapyInnateLung CancerNatural killer - NK

Identifiers

PMID39939140
PMCPMC11822435

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.