Evidence map›Paper›PMID 39939490›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Inhibitory effects of cornuside on human liver cytochrome P450 enzymes.

Yanmo Yang, Ke Zhang, Mi Zhou

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yanmo YangDepartment of Pharmacy, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), No. 388, Renmin Road, Wuling District, Changde City, 415000, Hunan Province, China.
Ke ZhangDepartment of Science and Education, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, 415000, China.
Mi ZhouDepartment of Pharmacy, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), No. 388, Renmin Road, Wuling District, Changde City, 415000, Hunan Province, China. Zhoumicdsyy@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cornuside is an iridoid glycoside isolated from the fruits of Cornus officinalis Sieb. et Zucc. with antiallergic and hypoglycemic properties. This study aimed to investigate the interaction of cornuside with cytochrome P450 (CYP) enzymes which may provide a reference for the clinical application of Cornus officinalis. The impact of cornuside on CYP enzyme activity in human liver microsomes (HLMs) was examined in the presence of 0, 2.5, 5, 10, 25, 50, and 100 µM of cornuside. In order to estimate the inhibition properties, Lineweaver-Burk plots were plotted and kinetic parameters were obtained. Furthermore, the time-dependent inhibition of CYP3A4 activity by cornuside was also assessed. The activity of CYP3A4, 2C19, and 2E1 was suppressed by cornuside, with half-maximal inhibitory concentration (IC

Indexed as

Cytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemIridoid GlycosidesCornusCytochrome P-450 CYP2C19Cytochrome P-450 CYP3ADose-Response Relationship, DrugHumansMicrosomes, LiverCYP2C19 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP3ACytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemIridoid GlycosidesCornusideCytochrome P450Human liver microsomesInhibition

Identifiers

PMID39939490

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.