ArticleNature2025
Intrinsic electrical activity drives small-cell lung cancer progression.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Genes, fuel, and fate in lung cancer.Biochemical Society transactions · 2026Review
- Ion Channel-Targeting Modulators in Glioma: Pharmacological Advances and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Neuroscience in prostate cancer.Prostate cancer and prostatic diseases · 2026Review
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- α-KG conformationally stabilizes nuclear GLUD1-SNAIL complex to fuel trans-endothelial migration in metastasis.Nature communications · 2026Article
- The neuronal network of small cell lung cancer: a narrative review of the role of the nervous system in the pathogenesis and progression.Translational lung cancer research · 2026Review
- BraMARS: An Interpretable Histopathology-Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited-Stage SCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nicotinic Acid Restriction Enhances the Therapeutic Benefit of NAMPT Inhibition in Small-Cell Lung Cancer Models.Cancer science · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Distinct Malignant Cell States and Myeloid Glutamate Signaling Associated with Aggressive Pancreatic Neuroendocrine Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Molecular mechanisms and therapeutic targets in lung cancer-nerve crosstalk.Chinese medical journal pulmonary and critical care medicine · 2026Review
- Research progress on immune microenvironment and biomarkers of small cell lung cancer.Journal of thoracic disease · 2026Review
- Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany.Journal of cancer research and clinical oncology · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
- Pan-Cancer Prognostic Analysis of NMDAR Genes Discovered Therapeutic Implications of Neuronal-Cancer Crosstalk Mediator GRIN2A for Small Cell Lung Cancer.Biomedicines · 2026Article
- Cancer: A bioelectric disease?Clinical and translational medicine · 2026Review
- Article
- The 2025 lung cancer landscape: advances in screening, molecular taxonomy and therapeutic strategy: a narrative review.Translational lung cancer research · 2026Review
- Neuro-tumor interactions in peripheral tumors.Cancer metastasis reviews · 2026Review
- Regulation of tumor proliferation by unlocking silent synapses on metastatic cancer cells.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Paola Peinado *Cancer Neuroscience Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-2484-928X
Marco Stazi *Cancer Neuroscience Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-8193-1610
Claudio Ballabio *Cancer Neuroscience Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0001-6632-1489
Michael-Bogdan MargineanuCancer Neuroscience Laboratory, Francis Crick Institute, London, UK.
Zhaoqi LiKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Caterina I ColónKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Min-Shu HsiehDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Shreoshi Pal ChoudhuriHamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1600-7664
Victor StastnyHamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Seth HamiltonHamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0008-3841-7799
Alix Le MaroisTumour Cell Biology Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0003-4464-4089
Jodie CollingridgeDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0952-6151
Linus ConradDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Yinxing ChenKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Sheng Rong NgKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-1655-2443
Margaret MagendantzKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Arjun BhutkarKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jin-Shing ChenDivision of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Erik SahaiTumour Cell Biology Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-3932-5086
Benjamin J DrapkinHamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-4824-7243
Tyler JacksKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-5785-8911
Matthew G Vander HeidenKoch Institute of Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-6702-4192
Maksym V KopanitsaCancer Neuroscience Laboratory, Francis Crick Institute, London, UK.
Hugh P C RobinsonCancer Neuroscience Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0002-5048-9954
Leanne LiCancer Neuroscience Laboratory, Francis Crick Institute, London, UK. leanne.li@crick.ac.uk.ORCID 0000-0002-1598-1564
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Kristin A Knouse · 1985 to 2026
$93.9MUnderstanding the role of metabolism in cancerR35CA242379 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VANDER HEIDEN, MATTHEW G. · 2019 to 2025
$5.8MDissecting and overcoming cross-resistance to DNA damaging agents in SCLCK08CA237832 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DRAPKIN, BENJAMIN J · 2020 to 2024
$1.2MNCI NIH HHS K08 CA237832NCI NIH HHS P30 CA014051NCI NIH HHS R35 CA242379Wellcome Trust CC2040Wellcome Trust CC2165
Abstract
Elevated or ectopic expression of neuronal receptors promotes tumour progression in many cancer types
Indexed as
Action PotentialsDisease ProgressionLung NeoplasmsSmall Cell Lung CarcinomaAdenosine TriphosphateAnimalsCell Line, TumorFemaleGlycolysisHumansMaleMiceNeuronsOxidative PhosphorylationAdenosine Triphosphate
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.