Evidence map›Paper›PMID 39939798›Full record

ArticleCell death and differentiation2025

STING directly interacts with PAR to promote apoptosis upon acute ionizing radiation-mediated DNA damage.

Yirong Sun, Saba R Aliyari, Kislay Parvatiyar, Lulan Wang, Anjie Zhen, Wei Sun, Xiaobo Han, Adele Zhang, Ethan Kato, Helen Shi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  18. Article
  19. Pro-Dermcidin as an Emerging Regulator of Innate Immunity in Sepsis.International journal of molecular sciences · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yirong Sun *CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. sun_yirong@gibh.ac.cn.ORCID 0000-0002-0617-5595
Saba R Aliyari *Department of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Kislay ParvatiyarDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Lulan WangDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Anjie ZhenDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Wei SunCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Xiaobo HanCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Adele ZhangDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Ethan KatoDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Helen ShiDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
Elena De SchutterDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA.
William H McBrideDepartment of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA, USA.
Samuel W FrenchDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7611-881X
Genhong ChengDepartment of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA, USA. gcheng@mednet.ucla.edu.

Funding

UCLA Center for Biological RadioprotectorsU19AI067769 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHUTE, JOHN P, MCBRIDE, WILLIAM H. · 2005 to 2019
$44.6M
Guangdong Science and Technology Department (Science and Technology Department, Guangdong Province) 2024A1515013177Natural Science Foundation of Tianjin Municipal Science and Technology Commission (Natural Science Foundation of Tianjin Municipal Science & Technology Commission) TSBICIP-KJGG-011NIAID NIH HHS U19 AI067769
6 · The paper itself

Abstract

Acute ionizing radiation (IR) causes severe DNA damage, leading to cell cycle arrest, cell death, and activation of the innate immune system. The role and signaling pathway of stimulator of interferon genes (STING) in IR-induced tissue damage and cell death are not well understood. This study revealed that STING is crucial for promoting apoptosis in response to DNA damage caused by acute IR both in vitro and in vivo. STING binds to poly (ADP‒ribose) (PAR) produced by activated poly (ADP‒ribose) polymerase-1 (PARP1) upon IR. Compared with that in WT cells, apoptosis was suppressed in Sting

Indexed as

ApoptosisDNA DamageMembrane ProteinsPoly Adenosine Diphosphate RibosePoly (ADP-Ribose) Polymerase-1Radiation, IonizingAnimalsApoptosis Regulatory Proteinsbcl-2-Associated X ProteinHumansMiceMice, Inbred C57BLSTING ProteinTumor Suppressor ProteinsApoptosis Regulatory Proteinsbcl-2-Associated X ProteinMembrane ProteinsParp1 protein, mousePoly Adenosine Diphosphate RibosePoly (ADP-Ribose) Polymerase-1PUMA protein, mouseSting1 protein, mouseSTING ProteinTumor Suppressor Proteins

Identifiers

PMID39939798
PMCPMC12163073

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.