Evidence map›Paper›PMID 39939827›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

Metabolic phenotypes and fatty acid profiles associated with histopathology of primary aldosteronism.

Yuhong Yang, Yuqing Liu, Tracy Ann Williams, Maoting Gao, Yutong Yan, Meiling Bao, Jun Tao, Guodong Ma, Min Wang, Zhiqing Xia and 3 more

Abstract read
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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yuhong Yang *Department of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Yuqing Liu *Department of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Tracy Ann Williams *Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, München, Germany.
Maoting GaoDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Yutong YanDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Meiling BaoDepartment of Pathology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Jun TaoDepartment of Urology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Guodong MaDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Min WangDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Zhiqing XiaDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.
Zhiheng ZhangDepartment of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. zhangzhihengfly@163.com.
Tao YangDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China. yangt@njmu.edu.cn.
Min SunDepartment of Endocrinology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China. drsunm@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary aldosteronism (PA) caused by aldosterone hypersecretion is treated by adrenalectomy or medications. Histopathologic examination of resected adrenals reveals diverse histopathologic features. This study aimed to investigate the potential association of peripheral and adrenal tissue metabolic profiles with the histopathologic features of PA. The retrospective study included 105 surgically treated and 43 medically treated patients with PA. Adrenal specimens were categorized according to the HISTALDO (HISTopathology of primary ALDOsteronism) consensus. Peripheral and adrenal tissue metabolic profiles were assessed, including adiposity, adipokines and fatty acid abundances. The distinct fatty acid, arachidonic acid, was further functionally characterized. Surgically treated patients with classical histopathologic findings (n = 71) displayed lower body mass indexes, a lower prevalence of obesity, smaller waist circumference and visceral adipose tissue areas, and lower leptin concentrations compared with operated patients with the nonclassical histopathology (n = 34). No such differences were identified between the nonclassical histopathology group and medically treated group. Distinct concentrations of 18 out of 35 peripheral venous fatty acids, including arachidonic acid, were identified among the 3 groups. Further, accumulation of arachidonic acid was demonstrated in 4 aldosterone-producing adenomas compared with paired adjacent cortex possibly linked with suppressed peroxisomal beta-oxidation. Stimulation of human adrenocortical cells with arachidonic acid or peroxisomal beta-oxidation inhibitor caused 3.8-fold (P = 0.0050) and 1.7-fold (P = 0.0328) amplification of CYP11B2 expression, respectively, which were ablated by BAPTA-AM or KN93, and induced oxidative stress and apoptosis. Our findings show metabolic heterogeneity related to histopathology and support a role for arachidonic acid in PA pathophysiology.

Indexed as

Fatty AcidsHyperaldosteronismAdrenal GlandsAdultAgedArachidonic AcidFemaleHumansMaleMiddle AgedPhenotypeRetrospective StudiesArachidonic AcidFatty AcidsAdrenal glandArachidonic acidFatty acidHistopathologyHyperaldosteronism

Identifiers

PMID39939827

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.