ArticleBMC pregnancy and childbirth2025
The association between inflammatory indices in early pregnancy and the risk of gestational diabetes mellitus in Chinese population.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Placenta-derived small extracellular vesicles transfer miR-520d-5p to mediate pancreatic β-cell injury in gestational diabetes mellitus by targeting SIRT1.BMC pregnancy and childbirth · 2026Article
- Role of second-trimester hematological and biochemical indicators in predicting preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Study on the predictive value of NHR and UHR levels in early pregnancy for gestational diabetes mellitus: based on a retrospective analysis.Frontiers in endocrinology · 2026Article
- Metabolic biomarkers in early detection of gestational diabetes mellitus: a prospective diagnostic accuracy study.Frontiers in medicine · 2026Article
- Elevated Systemic Immune-Inflammation Index is Associated with Gestational Diabetes Mellitus: A Multicenter Retrospective Studies.Journal of inflammation research · 2026Article
- Advances in gestational diabetes mellitus screening: Emerging trends and future directions.World journal of diabetes · 2025Review
- First trimester hepatic steatosis index as a predictor of gestational diabetes mellitus: a cohort study in Northwestern China.Scientific reports · 2025Article
- The association between gestational diabetes mellitus and cancer in women: an updated systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2025Article
- Maternal Immune Activation: Implications for Congenital Heart Defects.Clinical reviews in allergy & immunology · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe association between inflammatory indices from peripheral blood cell in early pregnancy and the risk of gestational diabetes mellitus (GDM) is unclear.
methodsThis was a retrospective study involving the medical data of 15,807 pregnant women who gave birth in 2019. Data were collected from the medical records and analyzed. The pregnant women's age, educational level, pre-pregnancy body weight, height, parity, family history of diabetes, lipid profile, blood pressure were recorded during 11 ~ 13
resultsIn the present study, a total of 15,807 women were included, including 2,355 (14.9%) women diagnosed with GDM. Women who were diagnosed with GDM showed markedly lower level of monocyte count and higher level of neutrophil and lymphocyte counts. The GDM group showed relatively lower level of SIRI, while no significant differences were found between GDM group and non-GDM group in MHR or SII. After adjusting for potential confounding factors, we observed a significant association between monocyte counts, MHR and the risk of developing GDM, and the risk tended to decrease with increasing levels of monocyte counts and MHR.
conclusionThe present study revealed that in early pregnancy, monocyte count and MHR have great potential as early diagnostic markers of GDM.
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