Evidence map›Paper›PMID 39940340›Full record

Trial reportNutrients2025

Effects of Oral Xylitol, Sucrose, and Acesulfame Potassium on Total Energy Intake During a Subsequent

Emilie Flad, Anita Altstädt, Christoph Beglinger, Jens F Rehfeld, Lukas Van Oudenhove, Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05671965 (Effects of Oral Xylitol on Subsequent Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite-related Sensations, and Gastrointestinal Tolerance), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05671965 nacompletednot on this map

Effects of Oral Xylitol on Subsequent Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite-related Sensations, and Gastrointestinal Tolerance

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2023 to 2024Enrolled21ConditionsEnergy Intake, Gastrointestinal Hormones, Glycemic Control, AppetiteArmsXylitol, Sucrose, Acesulfame Potassium, Water
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emilie FladSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0002-4510-5370
Anita AltstädtSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0009-0007-2204-6965
Christoph BeglingerSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.
Jens F RehfeldDepartment of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 1172 Copenhagen, Denmark.
Lukas Van OudenhoveLaboratory for Brain-Gut Axis Studies, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-6540-3113
Bettina K WölnerhanssenSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0003-3134-2743
Anne Christin Meyer-GerspachSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0003-4104-8812

Funding

Research Foundation Flanders 320030E_189329Swiss National Science Foundation 320030E_189329
6 · The paper itself

Abstract

BACKGROUND/

objectivesXylitol, a natural low-caloric bulk sweetener, is increasingly used as a sugar alternative due to its low-glycemic and low-insulinemic properties. The aim was to investigate the effect of orally administered xylitol, sucrose, and acesulfame potassium (ace-K) on energy intake during a subsequent

methodsIn this randomized, controlled, double-blind, crossover trial (ClinicalTrials.gov NCT05671965, 20 December 2022), we included 20 healthy participants with normal body weight. Over four study visits, participants consumed an oral preload containing 33.5 g xylitol, 33.5 g sucrose, or 0.1675 g ace-K dissolved in 300 mL water, or 300 mL pure water as control. Participants were provided with an

resultsTotal energy intake was lower in response to xylitol and ace-K compared to sucrose (

conclusionsThe consumption of oral preloads sweetened with xylitol or ace-K prior to an

Indexed as

Energy IntakeSucroseSweetening AgentsThiazinesXylitolAdministration, OralAdultBlood GlucoseCholecystokininCross-Over StudiesDouble-Blind MethodFemaleGlucagon-Like Peptide 1Healthy VolunteersHumansInsulinacetosulfameBlood GlucoseCholecystokininGlucagon-Like Peptide 1InsulinSucroseSweetening AgentsThiazinesXylitolacesulfame potassiumappetite-related sensationsenergy intakegastrointestinal satiation hormoneshealthy participantssucrosexylitol

Identifiers

PMID39940340
PMCPMC11821014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.